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Opinion|Videos|April 9, 2025

Optimizing CAR T for R/R CLL: Timing and Treatment Sequencing Strategies

Author(s)Caron A. Jacobson, MD, MMSc, Peter Riedell, MD

Experts discuss when to consider chimeric antigen receptor T-cell therapy (CAR T) for relapsed/refractory chronic lymphocytic leukemia (R/R CLL) patients and how to sequence CAR T and pirtobrutinib in clinical practice for those who have previously received both covalent Bruton tyrosine kinase (cBTK) inhibitor– and BCL2 inhibitor–containing regimens.

Episodes in this series

EP. 1 CAR-T in Second-Line DLBCL: When and for Whom?

EP. 1 CAR-T in Second-Line DLBCL: When and for Whom?

EP. 2 Real-World Data and CAR T Selection in Second-Line LBCL: Key Insights From ASH 2024

EP. 2 Real-World Data and CAR T Selection in Second-Line LBCL: Key Insights From ASH 2024

EP. 3 CAR-T in Third-Line-Plus LBCL: Treatment Sequencing and Patient Selection

EP. 3 CAR-T in Third-Line-Plus LBCL: Treatment Sequencing and Patient Selection

EP. 4 Guiding Patients Through CAR T: Key Discussion Points

EP. 4 Guiding Patients Through CAR T: Key Discussion Points

EP. 5 Future Directions for CAR T-Cell Therapy in LBCL: What’s Next?

EP. 5 Future Directions for CAR T-Cell Therapy in LBCL: What’s Next?

EP. 6 Optimizing CAR T for R/R CLL: Timing and Treatment Sequencing Strategies

EP. 6 Optimizing CAR T for R/R CLL: Timing and Treatment Sequencing Strategies

EP. 7 Novel Combination Therapies in First-Line CLL: Potential Impact of Treatment Sequencing

EP. 7 Novel Combination Therapies in First-Line CLL: Potential Impact of Treatment Sequencing

EP. 8 CAR T in CLL: Data Highlights and Long-Term Outcomes From ASH 2024

EP. 8 CAR T in CLL: Data Highlights and Long-Term Outcomes From ASH 2024

EP. 9 Overcoming Barriers and Improving CAR T Care in Academic and Community Settings

EP. 9 Overcoming Barriers and Improving CAR T Care in Academic and Community Settings

EP. 10 Key Takeaways: CAR T in Real-World Clinical Practice

EP. 10 Key Takeaways: CAR T in Real-World Clinical Practice

Video content above is prompted by the following:

Shifting focus to CLL, Dr Riedell,at what point do you consider CAR T-cell therapy for your R/R CLL patients?
How do you sequence between CAR T and pirtobrutinib in your clinical practice for those who have previously received both cBTK inhibitor– and BCL2 inhibitor–containing regimens?

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