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Opinion|Videos|March 26, 2025

Real-World Data and CAR T Selection in Second-Line LBCL: Key Insights From ASH 2024

Author(s)Caron A. Jacobson, MD, MMSc, Peter Riedell, MD

Experts discuss real-world outcomes of lisocabtagene maraleucel (liso-cel) as second-line therapy for relapsed/refractory large B-cell lymphoma (R/R LBCL), including data highlights from the CIMBTR registry and insights from a Matching-Adjusted Indirect Comparison (MAIC) of liso-cel vs axicabtagene ciloleucel (axi-cel) in the second-line setting, examining how these findings influence chimeric antigen receptor T-cell therapy (CAR T) selection and decision-making based on patient factors and disease characteristics.

Episodes in this series

EP. 1 CAR-T in Second-Line DLBCL: When and for Whom?

EP. 1 CAR-T in Second-Line DLBCL: When and for Whom?

EP. 2 Real-World Data and CAR T Selection in Second-Line LBCL: Key Insights From ASH 2024

EP. 2 Real-World Data and CAR T Selection in Second-Line LBCL: Key Insights From ASH 2024

EP. 3 CAR-T in Third-Line-Plus LBCL: Treatment Sequencing and Patient Selection

EP. 3 CAR-T in Third-Line-Plus LBCL: Treatment Sequencing and Patient Selection

EP. 4 Guiding Patients Through CAR T: Key Discussion Points

EP. 4 Guiding Patients Through CAR T: Key Discussion Points

EP. 5 Future Directions for CAR T-Cell Therapy in LBCL: What’s Next?

EP. 5 Future Directions for CAR T-Cell Therapy in LBCL: What’s Next?

EP. 6 Optimizing CAR T for R/R CLL: Timing and Treatment Sequencing Strategies

EP. 6 Optimizing CAR T for R/R CLL: Timing and Treatment Sequencing Strategies

EP. 7 Novel Combination Therapies in First-Line CLL: Potential Impact of Treatment Sequencing

EP. 7 Novel Combination Therapies in First-Line CLL: Potential Impact of Treatment Sequencing

EP. 8 CAR T in CLL: Data Highlights and Long-Term Outcomes From ASH 2024

EP. 8 CAR T in CLL: Data Highlights and Long-Term Outcomes From ASH 2024

EP. 9 Overcoming Barriers and Improving CAR T Care in Academic and Community Settings

EP. 9 Overcoming Barriers and Improving CAR T Care in Academic and Community Settings

EP. 10 Key Takeaways: CAR T in Real-World Clinical Practice

EP. 10 Key Takeaways: CAR T in Real-World Clinical Practice

Video content above is prompted by the following:

At ASH last year, there was an oral presentation looking at real-world outcomes of liso-cel as second-line therapy for R/R LBCL from the CIMBTR registry. What were some data highlights, and how do real-world outcomes influence your day-to-day decision-making?
What patient factors and/or disease characteristics do you consider when selecting between axi-cel vs liso-cel in the second-line setting? There was updated following from a MAIC of liso-cel vs axi-cel in the second line for R/R LBCL from ASH 2024. Has this data influenced your CAR T selection?

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