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Opinion|Videos|April 2, 2025

CAR-T in Third-Line-Plus LBCL: Treatment Sequencing and Patient Selection

Author(s)Caron A. Jacobson, MD, MMSc, Peter Riedell, MD

Experts discuss sequencing treatments in the third-line setting or beyond for patients who have not received chimeric antigen receptor T-cell therapy (CAR T) previously, comparing bispecific antibodies, CAR T, and other agents like polatuzumab and tafasitamab, while also considering patient factors and disease characteristics when selecting among available CAR-T options (axicabtagene ciloleucel [axi-cel], lisocabtagene maraleucel [liso-cel], and tisagenlecleucel [tisa-cel]).

Episodes in this series

EP. 1 CAR-T in Second-Line DLBCL: When and for Whom?

EP. 1 CAR-T in Second-Line DLBCL: When and for Whom?

EP. 2 Real-World Data and CAR T Selection in Second-Line LBCL: Key Insights From ASH 2024

EP. 2 Real-World Data and CAR T Selection in Second-Line LBCL: Key Insights From ASH 2024

EP. 3 CAR-T in Third-Line-Plus LBCL: Treatment Sequencing and Patient Selection

EP. 3 CAR-T in Third-Line-Plus LBCL: Treatment Sequencing and Patient Selection

EP. 4 Guiding Patients Through CAR T: Key Discussion Points

EP. 4 Guiding Patients Through CAR T: Key Discussion Points

EP. 5 Future Directions for CAR T-Cell Therapy in LBCL: What’s Next?

EP. 5 Future Directions for CAR T-Cell Therapy in LBCL: What’s Next?

EP. 6 Optimizing CAR T for R/R CLL: Timing and Treatment Sequencing Strategies

EP. 6 Optimizing CAR T for R/R CLL: Timing and Treatment Sequencing Strategies

EP. 7 Novel Combination Therapies in First-Line CLL: Potential Impact of Treatment Sequencing

EP. 7 Novel Combination Therapies in First-Line CLL: Potential Impact of Treatment Sequencing

EP. 8 CAR T in CLL: Data Highlights and Long-Term Outcomes From ASH 2024

EP. 8 CAR T in CLL: Data Highlights and Long-Term Outcomes From ASH 2024

EP. 9 Overcoming Barriers and Improving CAR T Care in Academic and Community Settings

EP. 9 Overcoming Barriers and Improving CAR T Care in Academic and Community Settings

EP. 10 Key Takeaways: CAR T in Real-World Clinical Practice

EP. 10 Key Takeaways: CAR T in Real-World Clinical Practice

Video content above is prompted by the following:

In the third-line setting or beyond, for those who did not receive CAR T previously, how are you sequencing among bispecific antibodies, CAR T, and other available agents (eg, polatuzumab, tafasitamab)?
What patient factors or disease characteristics do you take into account when choosing among the available CAR T-cell therapy options (axi-cel, liso-cel, tisa-cel?

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