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Opinion|Videos|December 12, 2024

Clinical Trial Considerations for eBC Treatment Selection

Author(s)Kevin Kalinsky, MD, MS, Virginia Kaklamani, MD

Panelists discuss how the NCCN guidelines for risk stratification in HR+/HER2– early-stage breast cancer (eBC) guide clinical decision-making, exploring real-world adherence to these guidelines, the complexity of risk stratification in various clinical scenarios, and the role of clinical factors, biomarkers, and advanced testing methodologies (including RSClin N+, next-generation sequencing [NGS], fluorescence in situ hybridization [FISH], immunohistochemistry [IHC], and circulating DNA [ctDNA]) in defining “high-risk” patients and guiding treatment strategies.

Episodes in this series

EP. 1 Introduction and HR+/HER2– eBC Overview

EP. 1 Introduction and HR+/HER2– eBC Overview

EP. 2 Approaches to eBC Diagnosis and Risk Stratification

EP. 2 Approaches to eBC Diagnosis and Risk Stratification

EP. 3 CDK4/6 Inhibitors Treatment Options in the eBC Setting

EP. 3 CDK4/6 Inhibitors Treatment Options in the eBC Setting

EP. 4 Clinical Trial Considerations for eBC Treatment Selection

EP. 4 Clinical Trial Considerations for eBC Treatment Selection

EP. 5 Clinical Decision-Making for a Patient With eBC: Scenario and Strategies

EP. 5 Clinical Decision-Making for a Patient With eBC: Scenario and Strategies

EP. 6 Managing CDK4/6 Inhibitor Toxicities and Encouraging Adherence

EP. 6 Managing CDK4/6 Inhibitor Toxicities and Encouraging Adherence

EP. 7 Multidisciplinary Treatment Sequencing and Coordination

EP. 7 Multidisciplinary Treatment Sequencing and Coordination

EP. 8 Summary of Recent Advances and Unmet Needs for Patients With eBC

EP. 8 Summary of Recent Advances and Unmet Needs for Patients With eBC

Video content above is prompted by the following:

How do you use adjuvant therapy in patients with HR+/HER2–eBC?
1. How do risk factors impact your adjuvant treatment strategy?
  1. Which risk factors are most influential, and why?
2. Please discuss some recent adjuvant CDK4/6 inhibitor studies in eBC:
  1. Abemaciclib + endocrine therapy
  2. Ribociclib + nonsteroidal aromatase inhibitor — Final analysis Node-negative (N0) subgroup analysis; NATALEE 4-y
  3. Palbociclib – analysis of the sensitivity to endocrine therapy assay in the PALLAS adjuvant trial of palbociclib Original PALLAS

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