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Opinion|Videos|December 18, 2024

Clinical Decision-Making for a Patient With eBC: Scenario and Strategies

Author(s)Kevin Kalinsky, MD, MS, Virginia Kaklamani, MD

Panelists discuss how differences in trial designs, including inclusion criteria, dosing, and end points, influence clinical decision-making in the use of CDK4/6 inhibitors for HR+/HER2– early breast cancer (eBC), with a focus on the NATALEE trial’s analysis of patients with no or low nodal involvement, and how recent expanded approval of ribociclib for high-risk node-positive and node-negative eBC patients guides the identification of ideal candidates based on clinical factors.

Episodes in this series

EP. 1 Introduction and HR+/HER2– eBC Overview

EP. 1 Introduction and HR+/HER2– eBC Overview

EP. 2 Approaches to eBC Diagnosis and Risk Stratification

EP. 2 Approaches to eBC Diagnosis and Risk Stratification

EP. 3 CDK4/6 Inhibitors Treatment Options in the eBC Setting

EP. 3 CDK4/6 Inhibitors Treatment Options in the eBC Setting

EP. 4 Clinical Trial Considerations for eBC Treatment Selection

EP. 4 Clinical Trial Considerations for eBC Treatment Selection

EP. 5 Clinical Decision-Making for a Patient With eBC: Scenario and Strategies

EP. 5 Clinical Decision-Making for a Patient With eBC: Scenario and Strategies

EP. 6 Managing CDK4/6 Inhibitor Toxicities and Encouraging Adherence

EP. 6 Managing CDK4/6 Inhibitor Toxicities and Encouraging Adherence

EP. 7 Multidisciplinary Treatment Sequencing and Coordination

EP. 7 Multidisciplinary Treatment Sequencing and Coordination

EP. 8 Summary of Recent Advances and Unmet Needs for Patients With eBC

EP. 8 Summary of Recent Advances and Unmet Needs for Patients With eBC

Video content above is prompted by the following:

Please describe notable differences in the trial designs or analyses (eg, inclusion criteria, dosing, end points) with these CDK4/6 inhibitors in eBC.
1. How do these differences impact your clinical decision-making?
2. The latest NATALEE trial analysis (N0 subgroup) examines patients with no or low nodal involvement; can you please describe your experience with this patient population?
With the recent expanded approval of ribociclib for node-positive and node-negative HR+/HER2– eBC patients with a high risk of recurrence, what patient characteristics or clinical factors make someone an ideal candidate for adjuvant ribociclib?

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