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Opinion|Videos|January 15, 2026

Contextualizing PFS, Safety, and Response Depth From DESTINY Breast09 in HER2 Positive Metastatic Breast Cancer

Author(s)Neil M. Iyengar, MD, William Gradishar, MD, Northwestern Medicine

Experts discuss the promising safety and efficacy of T-DXd in treating HER2-positive breast cancer, highlighting improved survival rates and response.

Episodes in this series

2 experts are featured in this series.

EP. 1 Evolving First-Line Management of HER2 Positive Metastatic Breast Cancer

2 experts are featured in this series.

EP. 2 DESTINY Breast09 Topline Findings in First-Line HER2 Positive Metastatic Breast Cancer

2 experts are featured in this series.

EP. 3 Contextualizing PFS, Safety, and Response Depth From DESTINY Breast09 in HER2 Positive Metastatic Breast Cancer

2 experts are featured in this series.

EP. 4 Sequencing Beyond First Line in HER2 Positive Metastatic Breast Cancer

This segment examines how clinicians should interpret progression free survival, safety, and response signals from DESTINY Breast09 within the context of established HER2 targeted evidence. Panelists discuss placing interim PFS findings alongside historical benchmarks from CLEOPATRA and later line data from DESTINY Breast03, emphasizing that cross trial comparisons require caution due to differences in populations and study design. Particular attention is given to safety considerations associated with trastuzumab deruxtecan, especially interstitial lung disease, with discussion of early recognition, monitoring protocols, and management strategies when considering earlier line use. The segment also addresses the higher complete response rate reported in interim analyses, exploring how depth of response may translate into meaningful clinical benefit only when supported by durable disease control and mature follow up. Clinicians are encouraged to balance enthusiasm for early efficacy signals with the need for longer term outcome data before altering established treatment paradigms.

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Working Together: Overcoming Barriers to Optimize Outcomes in Patients Treated With Radioligand Therapy Through Multidisciplinary Care

Working Together: Overcoming Barriers to Optimize Outcomes in Patients Treated With Radioligand Therapy Through Multidisciplinary Care

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21st Annual New York Lung Cancers Symposium®

In-Person Event

21st Annual New York Lung Cancers Symposium®

November 14, 2026

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

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Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

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Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

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