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Opinion|Videos|January 22, 2026

Evolving HER2 Expression and Biomarker Testing in Metastatic Breast Cancer

Author(s)Neil M. Iyengar, MD, William Gradishar, MD, Northwestern Medicine

Exploring the potential of T-DXd in HER2 therapy, including resistance mechanisms and optimal treatment sequencing for better patient outcomes.

Episodes in this series

2 experts are featured in this series.

EP. 1 Evolving First-Line Management of HER2 Positive Metastatic Breast Cancer

2 experts are featured in this series.

EP. 2 DESTINY Breast09 Topline Findings in First-Line HER2 Positive Metastatic Breast Cancer

2 experts are featured in this series.

EP. 3 Contextualizing PFS, Safety, and Response Depth From DESTINY Breast09 in HER2 Positive Metastatic Breast Cancer

2 experts are featured in this series.

EP. 4 Sequencing Beyond First Line in HER2 Positive Metastatic Breast Cancer

2 experts are featured in this series.

EP. 5 Evolving HER2 Expression and Biomarker Testing in Metastatic Breast Cancer

2 experts are featured in this series.

EP. 6 Integrating CNS Risk Into Treatment Sequencing for HER2 Positive Metastatic Breast Cancer

This segment explores how evolving concepts of HER2 expression are influencing therapeutic decision making in metastatic breast cancer. Panelists discuss the role of repeat tissue biopsy and liquid biopsy in capturing dynamic changes in HER2 status that may occur over the course of disease progression and treatment exposure. The conversation highlights how reassessment can inform eligibility for specific HER2 directed therapies and emerging ADCs. Attention is given to the growing recognition of HER2 low disease and whether the historical distinction between HER2 positive and HER2 low is beginning to narrow as newer agents demonstrate activity across a broader spectrum of HER2 expression. Clinicians reflect on how these developments may reshape testing algorithms, treatment selection, and future classification of HER2 driven disease. The segment emphasizes the importance of integrating molecular and pathologic data over time to ensure therapy remains aligned with evolving tumor biology and available targeted options.

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Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

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The Rise of Novel HER2-Targeting Therapies in GEA: Mechanisms and Clinical Data

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Revolutionizing TGCT Care with Multidisciplinary Perspectives and Cutting-Edge Targeted Therapies

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SimulatEd™: A Roadmap to Personalized Care Plans and Shared Decision-Making in Low-Grade Serous Ovarian Cancer

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