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Opinion|Videos|January 8, 2026

Evolving First-Line Management of HER2 Positive Metastatic Breast Cancer

Author(s)Neil M. Iyengar, MD, William Gradishar, MD, Northwestern Medicine

This opening segment sets the clinical foundation for the program by reviewing how treatment paradigms for HER2 positive metastatic breast cancer have evolved in recent years. The discussion introduces current guideline supported first line standards of care and highlights how the incorporation of antibody drug conjugates has expanded therapeutic possibilities beyond traditional chemotherapy and monoclonal antibody combinations. Panelists reflect on how these advances have reshaped long term disease management by improving response depth and extending disease control for many patients. Attention is also given to real world implementation, with comparison of adoption patterns across academic and community practices. Factors such as familiarity with novel agents, comfort managing ADC and TKI associated toxicities, and access to infusion resources are explored as drivers of variation in first line treatment selection. This segment establishes a practical framework for understanding how evolving evidence translates into everyday clinical decision making for patients with HER2 positive disease.

Episodes in this series

2 experts are featured in this series.

EP. 1 Evolving First-Line Management of HER2 Positive Metastatic Breast Cancer

2 experts are featured in this series.

EP. 2 DESTINY Breast09 Topline Findings in First-Line HER2 Positive Metastatic Breast Cancer

2 experts are featured in this series.

EP. 3 Contextualizing PFS, Safety, and Response Depth From DESTINY Breast09 in HER2 Positive Metastatic Breast Cancer

2 experts are featured in this series.

EP. 4 Sequencing Beyond First Line in HER2 Positive Metastatic Breast Cancer

This opening segment sets the clinical foundation for the program by reviewing how treatment paradigms for HER2 positive metastatic breast cancer have evolved in recent years. The discussion introduces current guideline supported first line standards of care and highlights how the incorporation of antibody drug conjugates has expanded therapeutic possibilities beyond traditional chemotherapy and monoclonal antibody combinations. Panelists reflect on how these advances have reshaped long term disease management by improving response depth and extending disease control for many patients. Attention is also given to real world implementation, with comparison of adoption patterns across academic and community practices. Factors such as familiarity with novel agents, comfort managing ADC and TKI associated toxicities, and access to infusion resources are explored as drivers of variation in first line treatment selection. This segment establishes a practical framework for understanding how evolving evidence transla

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Jason Hafron, MD; Aaron D. Berger, MD; Arpeet Shah, MD

BURST CME™ Resource Center: Integrating Novel PSMA-Directed Radioligand Approaches for Diagnosis and Management of Prostate Cancer

BURST CME™ Resource Center: Integrating Novel PSMA-Directed Radioligand Approaches for Diagnosis and Management of Prostate Cancer

Jeremie Calais, MD, PhD; Tanya B. Dorff, MD; Nerina McDonald, MSPAS, PA-C; Scott T. Tagawa, MD, MS, FACP, FASCO

Working Together: Overcoming Barriers to Optimize Outcomes in Patients Treated With Radioligand Therapy Through Multidisciplinary Care

Working Together: Overcoming Barriers to Optimize Outcomes in Patients Treated With Radioligand Therapy Through Multidisciplinary Care

Jeremie Calais, MD, PhD; Tanya B. Dorff, MD; Nerina McDonald, MSPAS, PA-C; Scott T. Tagawa, MD, MS, FACP, FASCO

21st Annual New York Lung Cancers Symposium®

In-Person Event

21st Annual New York Lung Cancers Symposium®

November 14, 2026

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Rahul Gosain, MD, MBA; Rohit Gosain, MD; Geoffery Ku, MD; Shruti Patel, MD

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Erminia Massarelli, MD, PhD, MS; Misty D. Shields, MD, PhD

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Yana G. Najjar, MD; Sapna Patel, MD

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