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Opinion|Videos|January 8, 2026

DESTINY Breast09 Topline Findings in First-Line HER2 Positive Metastatic Breast Cancer

Author(s)Neil M. Iyengar, MD, William Gradishar, MD, Northwestern Medicine

This segment highlights the interim topline efficacy findings from DESTINY Breast09 and explores their potential implications for first-line treatment of HER2 positive metastatic breast cancer. The discussion summarizes progression-free survival signals observed with trastuzumab deruxtecan with or without pertuzumab compared with the historical standard regimen of docetaxel, trastuzumab, and pertuzumab. Panelists emphasize that these results represent an early data readout and should be interpreted cautiously pending peer-reviewed publication, mature follow-up, and formal guideline integration. The conversation focuses on how these findings may challenge existing first-line paradigms by introducing an antibody drug conjugate earlier in the disease course, while reinforcing the importance of contextualizing DB09 within the broader HER2 evidence base. This segment sets the stage for subsequent discussion on safety, durability of benefit, and how emerging data may ultimately influence clinical practice once fully validated.

Episodes in this series

2 experts are featured in this series.

EP. 1 Evolving First-Line Management of HER2 Positive Metastatic Breast Cancer

2 experts are featured in this series.

EP. 2 DESTINY Breast09 Topline Findings in First-Line HER2 Positive Metastatic Breast Cancer

2 experts are featured in this series.

EP. 3 Contextualizing PFS, Safety, and Response Depth From DESTINY Breast09 in HER2 Positive Metastatic Breast Cancer

2 experts are featured in this series.

EP. 4 Sequencing Beyond First Line in HER2 Positive Metastatic Breast Cancer

This segment highlights the interim topline efficacy findings from DESTINY Breast09 and explores their potential implications for first-line treatment of HER2 positive metastatic breast cancer. The discussion summarizes progression-free survival signals observed with trastuzumab deruxtecan with or without pertuzumab compared with the historical standard regimen of docetaxel, trastuzumab, and pertuzumab. Panelists emphasize that these results represent an early data readout and should be interpreted cautiously pending peer-reviewed publication, mature follow-up, and formal guideline integration. The conversation focuses on how these findings may challenge existing first-line paradigms by introducing an antibody drug conjugate earlier in the disease course, while reinforcing the importance of contextualizing DB09 within the broader HER2 evidence base. This segment sets the stage for subsequent discussion on safety, durability of benefit, and how emerging data may ultimately influence clinical practice once fully validated.

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Medical Crossfire® in Adjunctive Testing: Charting a New Course in Prostate Cancer Risk Assessment

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BURST CME™ Resource Center: Integrating Novel PSMA-Directed Radioligand Approaches for Diagnosis and Management of Prostate Cancer

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Working Together: Overcoming Barriers to Optimize Outcomes in Patients Treated With Radioligand Therapy Through Multidisciplinary Care

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21st Annual New York Lung Cancers Symposium®

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Navigating the Adverse Event Landscape in HER2+ GEA Therapy

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Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

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Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

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