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Opinion|Videos|November 17, 2025

Current Treatment Approaches in NSCLC With PACC Mutations

Author(s)Jonathan Riess, MD, MS, UC Davis Comprehensive Cancer Center, Alexander I. Spira, MD, PhD

Panelists discuss how current TKI therapies offer limited efficacy for PACC mutations, necessitating individualized and trial-based approaches.

Episodes in this series

2 KOLs are featured in this program.

EP. 1 EGFR PACC Mutations in NSCLC

2 KOLs are featured in this program

EP. 2 EGFR PACC Mutation Identification Strategies in NSCLC

2 KOLs are featured in this program

EP. 3 Current Treatment Approaches in NSCLC With PACC Mutations

2 KOLs are featured in this program

EP. 4 Emerging Data on Firmonertinib for PACC Mutations in NSCLC

2 KOLs are featured in this program

EP. 5 Data From the FURTHER Trial in NSCLC With EGFR PACC Mutations

2 KOLs are featured in this program

EP. 6 Future Directions for NSCLC With PACC Mutations

Panelists discuss how existing tyrosine kinase inhibitors (TKIs)—first through third generation—demonstrate limited and variable activity against PACC mutations, reflecting the structural challenges these variants pose.

Panelists discuss how real-world treatment strategies often involve empiric use of later-generation TKIs or chemotherapy, with modest response rates compared to those seen in classical EGFR mutations.

Panelists discuss how clinicians must balance efficacy and tolerability while awaiting results from newer agents, emphasizing individualized decisions and the integration of clinical trial opportunities for eligible patients.

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