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Opinion|Videos|November 17, 2025

Emerging Data on Firmonertinib for PACC Mutations in NSCLC

Author(s)Jonathan Riess, MD, MS, UC Davis Comprehensive Cancer Center, Alexander I. Spira, MD, PhD

Panelists discuss how firmonertinib shows promise as a next-generation TKI with broad EGFR activity and favorable tolerability.

Episodes in this series

2 KOLs are featured in this program.

EP. 1 EGFR PACC Mutations in NSCLC

2 KOLs are featured in this program

EP. 2 EGFR PACC Mutation Identification Strategies in NSCLC

2 KOLs are featured in this program

EP. 3 Current Treatment Approaches in NSCLC With PACC Mutations

2 KOLs are featured in this program

EP. 4 Emerging Data on Firmonertinib for PACC Mutations in NSCLC

2 KOLs are featured in this program

EP. 5 Data From the FURTHER Trial in NSCLC With EGFR PACC Mutations

2 KOLs are featured in this program

EP. 6 Future Directions for NSCLC With PACC Mutations

Panelists discuss how firmonertinib, a fourth-generation EGFR tyrosine kinase inhibitor, has demonstrated promising properties such as strong central nervous system penetration and broad activity against classical and uncommon EGFR mutations.

Panelists discuss how it is already approved in China for EGFR-mutated non–small cell lung cancer (NSCLC) and is under global investigation in multiple settings, including first line, second line, and adjuvant therapy.

Panelists discuss how these studies may redefine the treatment landscape by offering a potentially more effective and better-tolerated option for patients with PACC-driven NSCLC.

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