
Opinion|Videos|November 24, 2025
Future Directions for NSCLC With PACC Mutations
Panelists discuss how novel agents and emerging strategies may further optimize sequencing and outcomes for EGFR PACC-mutated NSCLC.
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Episodes in this series

Panelists discuss how new agents such as amivantamab, sunvozertinib, and zipalertinib are expanding therapeutic possibilities for uncommon EGFR mutations, including PACC subtypes.
Panelists discuss how these data may guide sequencing strategies, combining different targeted modalities to overcome resistance and extend patient benefit.
Panelists discuss how emerging non–tyrosine kinase inhibitor approaches—such as antibody-drug conjugates and bispecific antibodies—could further diversify treatment options in the evolving non–small cell lung cancer (NSCLC)landscape.
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TRE-515 earned fast track status in combination with KRAS inhibitors for G12C-mutated NSCLC after anti–PD-(L)1 therapy and platinum-based chemotherapy.

An NDA for zipalertinib in EGFR exon 20 insertion–positive NSCLC is being supported by phase 3 REZILIENT3 data.

Did you catch all of this week's top oncology news? Test your knowledge with OncLive's Weekly News Quiz.

In case you missed any, read a recap of the episodes of OncLive On Air that aired in September 2026.

Estelamari Rodriguez, MD, MPH, discusses the rationale, design, and practice implications of the phase 3 RELATIVITY-1093 trial in nonsquamous NSCLC.

Plinabulin plus docetaxel received fast track designation for pretreated nonsquamous NSCLC without actionable genomic alterations.

Faculty convened at an OncLive Scientific Interchange and Workshop to discuss individualized treatment and strategic sequencing in HER2-mutated NSCLC.
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