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Opinion|Videos|January 7, 2026

Data for Frontline Zanubrutinib Plus Obinutuzumab and Venetoclax in Mantle Cell Lymphoma

Author(s)Michael Wang, MD, Nakhle Saba, MD

Michael Wang, MD, and Nakhle Saba, MD, discuss data for the frontline combination of zanubrutinib, obinutuzumab, and venetoclax in mantle cell lymphoma.

Episodes in this series

EP. 1 First-Line Treatment Approaches in Mantle Cell Lymphoma

EP. 1 First-Line Treatment Approaches in Mantle Cell Lymphoma

EP. 2 Factors Shaping Second-Line BTK Inhibitor Decisions in R/R Mantle Cell Lymphoma

EP. 2 Factors Shaping Second-Line BTK Inhibitor Decisions in R/R Mantle Cell Lymphoma

EP. 3 Results for Sonrotoclax Monotherapy in R/R Mantle Cell Lymphoma

EP. 3 Results for Sonrotoclax Monotherapy in R/R Mantle Cell Lymphoma

EP. 4 Data for Frontline Zanubrutinib Plus Obinutuzumab and Venetoclax in Mantle Cell Lymphoma

EP. 4 Data for Frontline Zanubrutinib Plus Obinutuzumab and Venetoclax in Mantle Cell Lymphoma

EP. 5 Navigating AEs With BTK Inhibitor–Based Therapies in Mantle Cell Lymphoma

EP. 5 Navigating AEs With BTK Inhibitor–Based Therapies in Mantle Cell Lymphoma

EP. 6 The Evolving Role of BTK and BCL2 Inhibitors in Mantle Cell Lymphoma

EP. 6 The Evolving Role of BTK and BCL2 Inhibitors in Mantle Cell Lymphoma

Michael Wang, MD, and Nakhle Saba, MD, discuss data from an investigator-initiated phase 2 trial (NCT03824483) evaluating the frontline combination of zanubrutinib (Brukinsa), obinutuzumab (Gazyva), and venetoclax (Venclexta) in mantle cell lymphoma. They highlight response rates, depth of remission, and early safety signals associated with this triplet regimen. Wang and Saba consider how this approach may challenge traditional chemoimmunotherapy paradigms.

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BURST CME™ Resource Center: Integrating Novel PSMA-Directed Radioligand Approaches for Diagnosis and Management of Prostate Cancer

BURST CME™ Resource Center: Integrating Novel PSMA-Directed Radioligand Approaches for Diagnosis and Management of Prostate Cancer

Jeremie Calais, MD, PhD; Tanya B. Dorff, MD; Nerina McDonald, MSPAS, PA-C; Scott T. Tagawa, MD, MS, FACP, FASCO

Working Together: Overcoming Barriers to Optimize Outcomes in Patients Treated With Radioligand Therapy Through Multidisciplinary Care

Working Together: Overcoming Barriers to Optimize Outcomes in Patients Treated With Radioligand Therapy Through Multidisciplinary Care

Jeremie Calais, MD, PhD; Tanya B. Dorff, MD; Nerina McDonald, MSPAS, PA-C; Scott T. Tagawa, MD, MS, FACP, FASCO

21st Annual New York Lung Cancers Symposium®

In-Person Event

21st Annual New York Lung Cancers Symposium®

November 14, 2026

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Navigating the Adverse Event Landscape in HER2+ GEA Therapy

Rahul Gosain, MD, MBA; Rohit Gosain, MD; Geoffery Ku, MD; Shruti Patel, MD

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Community Practice Connections™: Optimizing SCLC Treatment Strategies and Managing Adverse Events Across Disease Stages

Erminia Massarelli, MD, PhD, MS; Misty D. Shields, MD, PhD

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Community Practice Connections™: Enhancing Melanoma Outcomes With Intratumoral Oncolytic Immunotherapy–Strategies for the Multidisciplinary Team

Yana G. Najjar, MD; Sapna Patel, MD

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