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Opinion|Videos|January 7, 2026

Data for Frontline Zanubrutinib Plus Obinutuzumab and Venetoclax in Mantle Cell Lymphoma

Author(s)Michael Wang, MD, Nakhle Saba, MD

Michael Wang, MD, and Nakhle Saba, MD, discuss data for the frontline combination of zanubrutinib, obinutuzumab, and venetoclax in mantle cell lymphoma.

Episodes in this series

EP. 1 First-Line Treatment Approaches in Mantle Cell Lymphoma

EP. 1 First-Line Treatment Approaches in Mantle Cell Lymphoma

EP. 2 Factors Shaping Second-Line BTK Inhibitor Decisions in R/R Mantle Cell Lymphoma

EP. 2 Factors Shaping Second-Line BTK Inhibitor Decisions in R/R Mantle Cell Lymphoma

EP. 3 Results for Sonrotoclax Monotherapy in R/R Mantle Cell Lymphoma

EP. 3 Results for Sonrotoclax Monotherapy in R/R Mantle Cell Lymphoma

EP. 4 Data for Frontline Zanubrutinib Plus Obinutuzumab and Venetoclax in Mantle Cell Lymphoma

EP. 4 Data for Frontline Zanubrutinib Plus Obinutuzumab and Venetoclax in Mantle Cell Lymphoma

EP. 5 Navigating AEs With BTK Inhibitor–Based Therapies in Mantle Cell Lymphoma

EP. 5 Navigating AEs With BTK Inhibitor–Based Therapies in Mantle Cell Lymphoma

EP. 6 The Evolving Role of BTK and BCL2 Inhibitors in Mantle Cell Lymphoma

EP. 6 The Evolving Role of BTK and BCL2 Inhibitors in Mantle Cell Lymphoma

EP. 7 Other Key Mantle Cell Lymphoma Highlights From ASH 2025

EP. 7 Other Key Mantle Cell Lymphoma Highlights From ASH 2025

EP. 8 Ongoing Research to Watch in Mantle Cell Lymphoma in 2026 and Beyond

EP. 8 Ongoing Research to Watch in Mantle Cell Lymphoma in 2026 and Beyond

Michael Wang, MD, and Nakhle Saba, MD, discuss data from an investigator-initiated phase 2 trial (NCT03824483) evaluating the frontline combination of zanubrutinib (Brukinsa), obinutuzumab (Gazyva), and venetoclax (Venclexta) in mantle cell lymphoma. They highlight response rates, depth of remission, and early safety signals associated with this triplet regimen. Wang and Saba consider how this approach may challenge traditional chemoimmunotherapy paradigms.

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