Opinion|Videos|January 7, 2026
Data for Frontline Zanubrutinib Plus Obinutuzumab and Venetoclax in Mantle Cell Lymphoma
Author(s)Luhua (Michael) Wang, MD, Nakhle Saba, MD
Michael Wang, MD, and Nakhle Saba, MD, discuss data for the frontline combination of zanubrutinib, obinutuzumab, and venetoclax in mantle cell lymphoma.
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Michael Wang, MD, and Nakhle Saba, MD, discuss data from an investigator-initiated phase 2 trial (NCT03824483) evaluating the frontline combination of zanubrutinib (Brukinsa), obinutuzumab (Gazyva), and venetoclax (Venclexta) in mantle cell lymphoma. They highlight response rates, depth of remission, and early safety signals associated with this triplet regimen. Wang and Saba consider how this approach may challenge traditional chemoimmunotherapy paradigms.
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