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Opinion|Videos|January 7, 2026

Results for Sonrotoclax Monotherapy in R/R Mantle Cell Lymphoma

Author(s)Michael Wang, MD, Nakhle Saba, MD

Michael Wang, MD, and Nakhle Saba, MD, detail phase 1/2 findings for sonrotoclax in relapsed/refractory mantle cell lymphoma.

Episodes in this series

EP. 1 First-Line Treatment Approaches in Mantle Cell Lymphoma

EP. 1 First-Line Treatment Approaches in Mantle Cell Lymphoma

EP. 2 Factors Shaping Second-Line BTK Inhibitor Decisions in R/R Mantle Cell Lymphoma

EP. 2 Factors Shaping Second-Line BTK Inhibitor Decisions in R/R Mantle Cell Lymphoma

EP. 3 Results for Sonrotoclax Monotherapy in R/R Mantle Cell Lymphoma

EP. 3 Results for Sonrotoclax Monotherapy in R/R Mantle Cell Lymphoma

EP. 4 Data for Frontline Zanubrutinib Plus Obinutuzumab and Venetoclax in Mantle Cell Lymphoma

EP. 4 Data for Frontline Zanubrutinib Plus Obinutuzumab and Venetoclax in Mantle Cell Lymphoma

EP. 5 Navigating AEs With BTK Inhibitor–Based Therapies in Mantle Cell Lymphoma

EP. 5 Navigating AEs With BTK Inhibitor–Based Therapies in Mantle Cell Lymphoma

EP. 6 The Evolving Role of BTK and BCL2 Inhibitors in Mantle Cell Lymphoma

EP. 6 The Evolving Role of BTK and BCL2 Inhibitors in Mantle Cell Lymphoma

EP. 7 Other Key Mantle Cell Lymphoma Highlights From ASH 2025

EP. 7 Other Key Mantle Cell Lymphoma Highlights From ASH 2025

EP. 8 Ongoing Research to Watch in Mantle Cell Lymphoma in 2026 and Beyond

EP. 8 Ongoing Research to Watch in Mantle Cell Lymphoma in 2026 and Beyond

Michael Wang, MD, and Nakhle Saba, MD, review data from a phase 1/2 trial (NCT05471843) evaluating sonrotoclax monotherapy in relapsed/refractory mantle cell lymphoma. They discuss efficacy outcomes, response durability, and safety findings from early clinical experience. Wang and Saba place these results in context of existing treatment options for heavily pretreated patients.

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