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Opinion|Videos|January 14, 2026

The Evolving Role of BTK and BCL2 Inhibitors in Mantle Cell Lymphoma

Author(s)Luhua (Michael) Wang, MD, Nakhle Saba, MD

Michael Wang, MD, and Nakhle Saba, MD, discuss how ongoing research is shaping the evolving role of BTK and BCL2 inhibitors in mantle cell lymphoma.

Episodes in this series

EP. 1 First-Line Treatment Approaches in Mantle Cell Lymphoma

EP. 1 First-Line Treatment Approaches in Mantle Cell Lymphoma

EP. 2 Factors Shaping Second-Line BTK Inhibitor Decisions in R/R Mantle Cell Lymphoma

EP. 2 Factors Shaping Second-Line BTK Inhibitor Decisions in R/R Mantle Cell Lymphoma

EP. 3 Results for Sonrotoclax Monotherapy in R/R Mantle Cell Lymphoma

EP. 3 Results for Sonrotoclax Monotherapy in R/R Mantle Cell Lymphoma

EP. 4 Data for Frontline Zanubrutinib Plus Obinutuzumab and Venetoclax in Mantle Cell Lymphoma

EP. 4 Data for Frontline Zanubrutinib Plus Obinutuzumab and Venetoclax in Mantle Cell Lymphoma

EP. 5 Navigating AEs With BTK Inhibitor–Based Therapies in Mantle Cell Lymphoma

EP. 5 Navigating AEs With BTK Inhibitor–Based Therapies in Mantle Cell Lymphoma

EP. 6 The Evolving Role of BTK and BCL2 Inhibitors in Mantle Cell Lymphoma

EP. 6 The Evolving Role of BTK and BCL2 Inhibitors in Mantle Cell Lymphoma

EP. 7 Other Key Mantle Cell Lymphoma Highlights From ASH 2025

EP. 7 Other Key Mantle Cell Lymphoma Highlights From ASH 2025

EP. 8 Ongoing Research to Watch in Mantle Cell Lymphoma in 2026 and Beyond

EP. 8 Ongoing Research to Watch in Mantle Cell Lymphoma in 2026 and Beyond

Michael Wang, MD, and Nakhle Saba, MD, explore how ongoing research is redefining the role of BTK and BCL2 inhibitors in mantle cell lymphoma. They discuss combination strategies, sequencing considerations, and emerging clinical data. Wang and Saba highlight how these advances may further improve long-term disease control.

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