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Opinion|Videos|December 23, 2025

First-Line Treatment Approaches in Mantle Cell Lymphoma

Author(s)Luhua (Michael) Wang, MD, Nakhle Saba, MD

Michael Wang, MD, and Nakhle Saba, MD, highlight current frontline treatment approaches for mantle cell lymphoma.

Episodes in this series

EP. 1 First-Line Treatment Approaches in Mantle Cell Lymphoma

EP. 1 First-Line Treatment Approaches in Mantle Cell Lymphoma

EP. 2 Factors Shaping Second-Line BTK Inhibitor Decisions in R/R Mantle Cell Lymphoma

EP. 2 Factors Shaping Second-Line BTK Inhibitor Decisions in R/R Mantle Cell Lymphoma

EP. 3 Results for Sonrotoclax Monotherapy in R/R Mantle Cell Lymphoma

EP. 3 Results for Sonrotoclax Monotherapy in R/R Mantle Cell Lymphoma

EP. 4 Data for Frontline Zanubrutinib Plus Obinutuzumab and Venetoclax in Mantle Cell Lymphoma

EP. 4 Data for Frontline Zanubrutinib Plus Obinutuzumab and Venetoclax in Mantle Cell Lymphoma

EP. 5 Navigating AEs With BTK Inhibitor–Based Therapies in Mantle Cell Lymphoma

EP. 5 Navigating AEs With BTK Inhibitor–Based Therapies in Mantle Cell Lymphoma

EP. 6 The Evolving Role of BTK and BCL2 Inhibitors in Mantle Cell Lymphoma

EP. 6 The Evolving Role of BTK and BCL2 Inhibitors in Mantle Cell Lymphoma

EP. 7 Other Key Mantle Cell Lymphoma Highlights From ASH 2025

EP. 7 Other Key Mantle Cell Lymphoma Highlights From ASH 2025

EP. 8 Ongoing Research to Watch in Mantle Cell Lymphoma in 2026 and Beyond

EP. 8 Ongoing Research to Watch in Mantle Cell Lymphoma in 2026 and Beyond

Michael Wang, MD, and Nakhle Saba, MD, review current frontline treatment approaches for patients with mantle cell lymphoma. They discuss how patient age, disease risk, and fitness influence the selection of intensive vs less intensive strategies. Wang and Saba also highlight how targeted agents are increasingly shaping first-line decision-making.

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