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Opinion|Videos|December 23, 2025

Factors Shaping Second-Line BTK Inhibitor Decisions in R/R Mantle Cell Lymphoma

Author(s)Luhua (Michael) Wang, MD, Nakhle Saba, MD

Michael Wang, MD, and Nakhle Saba, MD, discuss factors that drive BTK inhibitor selection in second-line mantle cell lymphoma.

Episodes in this series

EP. 1 First-Line Treatment Approaches in Mantle Cell Lymphoma

EP. 1 First-Line Treatment Approaches in Mantle Cell Lymphoma

EP. 2 Factors Shaping Second-Line BTK Inhibitor Decisions in R/R Mantle Cell Lymphoma

EP. 2 Factors Shaping Second-Line BTK Inhibitor Decisions in R/R Mantle Cell Lymphoma

EP. 3 Results for Sonrotoclax Monotherapy in R/R Mantle Cell Lymphoma

EP. 3 Results for Sonrotoclax Monotherapy in R/R Mantle Cell Lymphoma

EP. 4 Data for Frontline Zanubrutinib Plus Obinutuzumab and Venetoclax in Mantle Cell Lymphoma

EP. 4 Data for Frontline Zanubrutinib Plus Obinutuzumab and Venetoclax in Mantle Cell Lymphoma

EP. 5 Navigating AEs With BTK Inhibitor–Based Therapies in Mantle Cell Lymphoma

EP. 5 Navigating AEs With BTK Inhibitor–Based Therapies in Mantle Cell Lymphoma

EP. 6 The Evolving Role of BTK and BCL2 Inhibitors in Mantle Cell Lymphoma

EP. 6 The Evolving Role of BTK and BCL2 Inhibitors in Mantle Cell Lymphoma

EP. 7 Other Key Mantle Cell Lymphoma Highlights From ASH 2025

EP. 7 Other Key Mantle Cell Lymphoma Highlights From ASH 2025

EP. 8 Ongoing Research to Watch in Mantle Cell Lymphoma in 2026 and Beyond

EP. 8 Ongoing Research to Watch in Mantle Cell Lymphoma in 2026 and Beyond

Michael Wang, MD, and Nakhle Saba, MD, discuss key factors that guide BTK inhibitor selection in the second-line setting for relapsed/refractory mantle cell lymphoma. They examine how prior therapy, toxicity profiles, comorbidities, and disease biology affect treatment choice. Wang and Saba emphasize the importance of individualized decision-making when sequencing BTK inhibitors.

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