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Opinion|Videos|January 12, 2026

Data for Venetoclax/Azacitidine in Induction-Eligible AML: The PARADIGM Trial

Author(s)Courtney DiNardo, MD, MSCE, Jessica K. Altman, MD

Courtney D. DiNardo, MD, MSCE, and Jessica K. Altman, MD, discuss data for venetoclax plus azacitidine vs induction chemotherapy in newly diagnosed, fit AML.

Episodes in this series

EP. 1 Rationale Behind Triplet Therapy Research in Acute Myeloid Leukemia

EP. 1 Rationale Behind Triplet Therapy Research in Acute Myeloid Leukemia

EP. 2 Exploring Triplet Therapies in IDH-Mutated AML

EP. 2 Exploring Triplet Therapies in IDH-Mutated AML

EP. 3 Identifying Populations for Triplet Therapy in AML

EP. 3 Identifying Populations for Triplet Therapy in AML

EP. 4 Data for Venetoclax/Azacitidine in Induction-Eligible AML: The PARADIGM Trial

EP. 4 Data for Venetoclax/Azacitidine in Induction-Eligible AML: The PARADIGM Trial

EP. 5 Potential Triplet Strategies in KMT2A+ AML

EP. 5 Potential Triplet Strategies in KMT2A+ AML

EP. 6 Addressing Potential Relapses After Transplant in AML

EP. 6 Addressing Potential Relapses After Transplant in AML

EP. 7 Dose Modification Strategies With Triplet Therapies in AML

EP. 7 Dose Modification Strategies With Triplet Therapies in AML

EP. 8 Other Key AML Data to Emerge From ASH 2025

EP. 8 Other Key AML Data to Emerge From ASH 2025

Courtney D. DiNardo, MD, MSCE, and Jessica K. Altman, MD, examine data from the phase 2 PARADIGM trial (NCT04801797) comparing venetoclax (Venclexta) plus azacitidine vs standard induction chemotherapy in newly diagnosed, fit patients with acute myeloid leukemia (AML). They discuss key efficacy outcomes, safety considerations, and how these results challenge traditional distinctions between intensive and lower-intensity therapy. They also consider the implications of these findings for frontline treatment decision-making.

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