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Opinion|Videos|January 5, 2026

Exploring Triplet Therapies in IDH-Mutated AML

Author(s)Courtney DiNardo, MD, MSCE, Jessica K. Altman, MD

Courtney D. DiNardo, MD, MSCE, and Jessica K. Altman, MD, discuss data from MD Anderson Cancer Center on triplet therapies in AML with IDH mutations.

Episodes in this series

EP. 1 Rationale Behind Triplet Therapy Research in Acute Myeloid Leukemia

EP. 1 Rationale Behind Triplet Therapy Research in Acute Myeloid Leukemia

EP. 2 Exploring Triplet Therapies in IDH-Mutated AML

EP. 2 Exploring Triplet Therapies in IDH-Mutated AML

EP. 3 Identifying Populations for Triplet Therapy in AML

EP. 3 Identifying Populations for Triplet Therapy in AML

EP. 4 Data for Venetoclax/Azacitidine in Induction-Eligible AML: The PARADIGM Trial

EP. 4 Data for Venetoclax/Azacitidine in Induction-Eligible AML: The PARADIGM Trial

EP. 5 Potential Triplet Strategies in KMT2A+ AML

EP. 5 Potential Triplet Strategies in KMT2A+ AML

EP. 6 Addressing Potential Relapses After Transplant in AML

EP. 6 Addressing Potential Relapses After Transplant in AML

EP. 7 Dose Modification Strategies With Triplet Therapies in AML

EP. 7 Dose Modification Strategies With Triplet Therapies in AML

EP. 8 Other Key AML Data to Emerge From ASH 2025

EP. 8 Other Key AML Data to Emerge From ASH 2025

Courtney D. DiNardo, MD, MSCE, and Jessica K. Altman, MD, review data from a study published at The University of Texas MD Anderson Cancer Center evaluating triplet therapy approaches in patients with IDH-mutated acute myeloid leukemia (AML). They discuss early efficacy signals, response depth, and tolerability observed with combinations incorporating IDH inhibitors. DiNardo and Altman place these findings in context of evolving treatment paradigms for molecularly defined AML subsets.

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