Exploring Triplet Therapies in IDH-Mutated AML

Courtney D. DiNardo, MD, MSCE, and Jessica K. Altman, MD, review data from a study published at The University of Texas MD Anderson Cancer Center evaluating triplet therapy approaches in patients with IDH-mutated acute myeloid leukemia (AML). They discuss early efficacy signals, response depth, and tolerability observed with combinations incorporating IDH inhibitors. DiNardo and Altman place these findings in context of evolving treatment paradigms for molecularly defined AML subsets.