Opinion|Videos|January 19, 2026
Potential Triplet Strategies in KMT2A+ AML
Courtney D. DiNardo, MD, MSCE, and Jessica K. Altman, MD, discuss potential triplet strategies with menin inhibitors for KMT2A-rearranged AML.
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Courtney D. DiNardo, MD, MSCE, and Jessica K. Altman, MD, explore emerging triplet strategies incorporating menin inhibitors for patients with KMT2A-rearranged acute myeloid leukemia (AML). They review the biological rationale for targeting menin and how these agents may synergize with established backbones such as venetoclax (Venclexta)-based regimens. DiNardo and Altman discuss how these combinations could address historically poor outcomes in this high-risk population.
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