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Opinion|Videos|January 5, 2026

Rationale Behind Triplet Therapy Research in Acute Myeloid Leukemia

Author(s)Courtney DiNardo, MD, MSCE, Jessica K. Altman, MD

Courtney D. DiNardo, MD, MSCE, and Jessica K. Altman, MD, discuss the rationale for investigating triplet therapies in acute myeloid leukemia.

Episodes in this series

EP. 1 Rationale Behind Triplet Therapy Research in Acute Myeloid Leukemia

EP. 1 Rationale Behind Triplet Therapy Research in Acute Myeloid Leukemia

EP. 2 Exploring Triplet Therapies in IDH-Mutated AML

EP. 2 Exploring Triplet Therapies in IDH-Mutated AML

EP. 3 Identifying Populations for Triplet Therapy in AML

EP. 3 Identifying Populations for Triplet Therapy in AML

EP. 4 Data for Venetoclax/Azacitidine in Induction-Eligible AML: The PARADIGM Trial

EP. 4 Data for Venetoclax/Azacitidine in Induction-Eligible AML: The PARADIGM Trial

EP. 5 Potential Triplet Strategies in KMT2A+ AML

EP. 5 Potential Triplet Strategies in KMT2A+ AML

EP. 6 Addressing Potential Relapses After Transplant in AML

EP. 6 Addressing Potential Relapses After Transplant in AML

EP. 7 Dose Modification Strategies With Triplet Therapies in AML

EP. 7 Dose Modification Strategies With Triplet Therapies in AML

EP. 8 Other Key AML Data to Emerge From ASH 2025

EP. 8 Other Key AML Data to Emerge From ASH 2025

Courtney D. DiNardo, MD, MSCE, and Jessica K. Altman, MD, discuss the scientific and clinical rationale driving the investigation of triplet therapy approaches in acute myeloid leukemia (AML). They explain how resistance mechanisms, disease heterogeneity, and suboptimal durability of current doublet regimens have prompted exploration of more intensive combinations. DiNardo and Altman also outline how advances in targeted therapies have made rational triplet strategies increasingly feasible.

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