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Opinion|Videos|January 12, 2026

Identifying Populations for Triplet Therapy in AML

Author(s)Courtney DiNardo, MD, MSCE, Jessica K. Altman, MD

Courtney D. DiNardo, MD, MSCE, and Jessica K. Altman, MD, detail populations in AML that could derive benefit from triplet therapies.

Episodes in this series

EP. 1 Rationale Behind Triplet Therapy Research in Acute Myeloid Leukemia

EP. 1 Rationale Behind Triplet Therapy Research in Acute Myeloid Leukemia

EP. 2 Exploring Triplet Therapies in IDH-Mutated AML

EP. 2 Exploring Triplet Therapies in IDH-Mutated AML

EP. 3 Identifying Populations for Triplet Therapy in AML

EP. 3 Identifying Populations for Triplet Therapy in AML

EP. 4 Data for Venetoclax/Azacitidine in Induction-Eligible AML: The PARADIGM Trial

EP. 4 Data for Venetoclax/Azacitidine in Induction-Eligible AML: The PARADIGM Trial

EP. 5 Potential Triplet Strategies in KMT2A+ AML

EP. 5 Potential Triplet Strategies in KMT2A+ AML

EP. 6 Addressing Potential Relapses After Transplant in AML

EP. 6 Addressing Potential Relapses After Transplant in AML

EP. 7 Dose Modification Strategies With Triplet Therapies in AML

EP. 7 Dose Modification Strategies With Triplet Therapies in AML

EP. 8 Other Key AML Data to Emerge From ASH 2025

EP. 8 Other Key AML Data to Emerge From ASH 2025

Courtney D. DiNardo, MD, MSCE, and Jessica K. Altman, MD, detail which patient populations with acute myeloid leukemia (AML) may derive the greatest benefit from triplet therapy approaches. They discuss how disease biology, fitness, and molecular risk factors influence patient selection. DiNardo and Altman emphasize the importance of balancing efficacy gains with safety when considering intensified regimens.

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