Dr. Ailawadhi on the Emergence of T-Cell Engagers in Multiple Myeloma

Video

In Partnership With:

Sikander Ailawadhi, MD, discusses the emergence of T-cell engagers in multiple myeloma.

Sikander Ailawadhi, MD, professor of medicine, Division of Hematology/Oncology, Departments of Medicine and Cancer Biology, Mayo Clinic, discusses the emergence of T-cell engagers in multiple myeloma.

During the virtual 2020 ASH Annual Meeting & Exposition, data regarding bispecific antibodies and antibody-drug conjugates (ADCs), were presented. Moreover, MEDI2228, a BCMA-directed ADC, and AMG 701, a BCMA-directed bispecific T-cell engager, demonstrated encouraging early efficacy in relapsed/refractory multiple myeloma. Utilizing T-cell engager therapies in multiple myeloma may provide patients with deep, sustained responses and limited early toxicity, Ailawadhi explains.

Comparatively, CAR T-cell therapy is also emerging into the myeloma space, Ailawadhi explains. Although these data are maturing, the cellular therapy appears to induce deep, early responses that may not be sustained. As such, T-cell engagers could offer patients who progress after CAR T-cell therapy, along with those who are not candidates for CAR T-cell therapy, the opportunity to derive sustained responses without significant toxicity, concludes Ailawadhi.

Related Videos
Ricardo D. Parrondo, MD, hematologist/oncologist, Mayo Clinic
Ilyas Sahin, MD
Raj Singh, MD
Jaime R. Merchán, MD, professor, co-leader, Translational and Clinical Oncology Research Program, director, Phase 1 Clinical Trials Program, Department of Medicine, Division of Medical Oncology, the University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center
Saad J. Kenderian, MB, CHB
Tycel Phillips, MD
Minesh Mehta, MD
Shivaani Kummar, MBBS, FACP, Margaret and Lester DeArmond Endowed Chair of Cancer Research, Professor and Division Head, Division of Hematology/Medical Oncology, Oregon Health & Science University School of Medicine; co-director, Center for Experimental Therapeutics, co-deputy director, Knight Cancer Institute
Andre Goy, MD
Wenxin (Vincent) Xu, MD,