Video

Dr. Sung Choi on Vorinostat in GVHD Prevention

Sung W. Choi, MD, Assistant Professor, University of Michigan, discusses the results of a phase I/II trial examining the use of the histone deacetylase (HDAC) inhibitor vorinostat in graft-versus-host disease (GVHD) prevention.

Sung W. Choi, MD, Assistant Professor, University of Michigan, discusses the results of a phase I/II trial examining the use of the histone deacetylase (HDAC) inhibitor vorinostat in graft-versus-host disease (GVHD) prevention.

Bone marrow transplantation is a potentially curative therapy for many hematological cancers as well as non-malignant conditions. GVHD remains a barrier to successful transplantation, Choi says, yet prevention therapies have not made much progress in the past 20 to 30 years.

The trial used a standard conditioning background of fludarabine and busulfan along with standard GVHD prophylaxis (tacrolimus and mycophenolate mofetil) then added the investigational agent, vorinostat. The combination was taken for 111 days before, during, and after bone marrow transplant.

The primary endpoint was the cumulative incidence of grade 2-4 acute GVHD with a target risk of 25% by day 100. The endpoint was reached: the cumulative incidence of day 100 grade 2-4 acute GVHD was 21% in the study group compared to 48% in the control, according to Choi. Further, transplant-related mortality was reduced and overall survival saw improvement in the study arm.

Related Videos
Julia Rotow, MD, clinical director, Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute; assistant professor, medicine, Harvard Medical School
Joshua K. Sabari, MD, assistant professor, Department of Medicine, New York University Grossman School of Medicine; director, High Reliability Organization Initiatives, Perlmutter Cancer Center
Alastair Thompson, BSc, MBChB, MD, FRCS
C. Ola Landgren, MD, PhD
Sara M. Tolaney, MD, MPH
Adam M. Brufsky, MD, PhD, FACP
Justin M. Watts, MD
Sara M. Tolaney, MD, MPH
Leah Backhus, MD, MPH, FACS, professor, University Medical Line, Cardiothoracic Surgery, co-director, Thoracic Surgery Clinical Research Program, associate program director, Thoracic Track, CT Surgery Residency Training Program, Thelma and Henry Doelger Professor of Cardiovascular Surgery, Stanford Medicine; chief, Thoracic Surgery, VA Palo Alto
Roy S. Herbst, MD, PhD, Ensign Professor of Medicine (Medical Oncology), professor, pharmacology, deputy director, Yale Cancer Center; chief, Medical Oncology, director, Center for Thoracic Cancers, Yale Cancer Center and Smilow Cancer Hospital; assistant dean, Translational Research, Yale School of Medicine