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Opinion|Videos|January 22, 2025

Efficacy and Potential of Revumenib in KMT2A-Translocated Leukemia

Author(s)Thomas W. LeBlanc, MD, MA, MHS, FAAHPM, FASCO , James Blachly, MD, Aaron Goldberg, MD, PhD Memorial Sloan Kettering Cancer Center

Panelists discuss the data updates from the AUGMENT-101 trial, the potential of revumenib to reshape the treatment landscape for patients with heavily pretreated KMT2A-rearranged acute leukemia, including its observed objective response rate (ORR) and complete remission (CR)/ CR with partial recovery of peripheral blood counts (CRh) rate, and the clinical implications of revumenib in the context of bridging to stem cell transplantation.

Episodes in this series

$EP. 1 Treatment Strategies for Relapsed/Refractory AML Patients$

EP. 1 Treatment Strategies for Relapsed/Refractory AML Patients

EP. 2 Treatment Goals and Unmet Needs in R/R AML

EP. 2 Treatment Goals and Unmet Needs in R/R AML

EP. 3 Navigating Challenges in Second- and Third-Line AML Therapy

EP. 3 Navigating Challenges in Second- and Third-Line AML Therapy

EP. 4 Revumenib’s FDA Approval and Clinical Implications

EP. 4 Revumenib’s FDA Approval and Clinical Implications

EP. 5 Efficacy and Potential of Revumenib in KMT2A-Translocated Leukemia

EP. 5 Efficacy and Potential of Revumenib in KMT2A-Translocated Leukemia

EP. 6 Adverse Event Management and Patient Safety With Revumenib

EP. 6 Adverse Event Management and Patient Safety With Revumenib

EP. 7 MRD Testing and the Role of Revumenib in Treatment Response

EP. 7 MRD Testing and the Role of Revumenib in Treatment Response

EP. 8 Integrating Revumenib Into Current R/R AML Treatment Paradigms

EP. 8 Integrating Revumenib Into Current R/R AML Treatment Paradigms

EP. 9 Genetic Testing and Molecular Profiling in AML

EP. 9 Genetic Testing and Molecular Profiling in AML

EP. 10 Emerging Combination Strategies and Preclinical Findings

EP. 10 Emerging Combination Strategies and Preclinical Findings

EP. 11 Future Perspectives on Menin Inhibitors in Acute Leukemias

EP. 11 Future Perspectives on Menin Inhibitors in Acute Leukemias

EP. 12 Closing Perspectives on R/R AML Treatment Advances

EP. 12 Closing Perspectives on R/R AML Treatment Advances

Video content above is prompted by the following:

Briefly comment on data updates presented for the AUGMENT-101 trial.
Given the 64% ORR and 23% CR/CRh rate observed with revumenib in patients with heavily preated pretreated KMT2A-rearranged acute leukemia patients, how do you see this therapy reshaping the treatment landscape for this high-risk population?
Briefly comment on the clinical implications, particularly in the context of bridging to stem cell transplantation.?

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