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Opinion|Videos|January 10, 2025

Navigating Challenges in Second- and Third-Line AML Therapy

Author(s)Thomas W. LeBlanc, MD, MA, MHS, FAAHPM, FASCO , James Blachly, MD, Aaron Goldberg, MD, PhD Memorial Sloan Kettering Cancer Center

Panelists discuss how treatment goals in the second- and third-line settings for relapsed/refractory acute monocytic leukemia (R/R AML) now focus more on disease control, quality of life, and prolonging survival, and explore the most significant unmet needs in R/R AML, particularly in addressing drug resistance and optimizing therapeutic strategies.

Episodes in this series

$EP. 1 Treatment Strategies for Relapsed/Refractory AML Patients$

EP. 1 Treatment Strategies for Relapsed/Refractory AML Patients

EP. 2 Treatment Goals and Unmet Needs in R/R AML

EP. 2 Treatment Goals and Unmet Needs in R/R AML

EP. 3 Navigating Challenges in Second- and Third-Line AML Therapy

EP. 3 Navigating Challenges in Second- and Third-Line AML Therapy

EP. 4 Revumenib’s FDA Approval and Clinical Implications

EP. 4 Revumenib’s FDA Approval and Clinical Implications

EP. 5 Efficacy and Potential of Revumenib in KMT2A-Translocated Leukemia

EP. 5 Efficacy and Potential of Revumenib in KMT2A-Translocated Leukemia

EP. 6 Adverse Event Management and Patient Safety With Revumenib

EP. 6 Adverse Event Management and Patient Safety With Revumenib

EP. 7 MRD Testing and the Role of Revumenib in Treatment Response

EP. 7 MRD Testing and the Role of Revumenib in Treatment Response

EP. 8 Integrating Revumenib Into Current R/R AML Treatment Paradigms

EP. 8 Integrating Revumenib Into Current R/R AML Treatment Paradigms

EP. 9 Genetic Testing and Molecular Profiling in AML

EP. 9 Genetic Testing and Molecular Profiling in AML

EP. 10 Emerging Combination Strategies and Preclinical Findings

EP. 10 Emerging Combination Strategies and Preclinical Findings

EP. 11 Future Perspectives on Menin Inhibitors in Acute Leukemias

EP. 11 Future Perspectives on Menin Inhibitors in Acute Leukemias

EP. 12 Closing Perspectives on R/R AML Treatment Advances

EP. 12 Closing Perspectives on R/R AML Treatment Advances

Video content above is prompted by the following:

Outside of cure, what are the treatment goals in the second-line and third-line setting?
How have these goals changed based on the recent changes within the AML landscape?
What do you see as the most significant unmet need in R/R AML?

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