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Opinion|Videos|February 26, 2025

Emerging Frontline, Adjuvant, and Neoadjuvant Strategies with T-DXd in HER2+ Breast Cancer

Author(s)Neil M. Iyengar, MD, Sara A. Hurvitz, MD, FACP , Laura Huppert, MD

Panelists discuss how emerging data from trials such as DESTINY-Breast09, which is evaluating first-line trastuzumab deruxtecan (T-DXd) with or without pertuzumab, could potentially reshape the treatment paradigm for HER2+ metastatic breast cancer (mBC) by establishing new standards for initial therapy and optimal combination approaches.

Episodes in this series

5 experts are featured in this series

EP. 1 Precision Medicine in Breast Cancer: Evolving Paradigms in HER2 Testing and Clinical Implications

5 experts are featured in this series

EP. 2 ADCs in HER2-Low Breast Cancer: Insights From DESTINY-Breast04, TROPiCS-02, and TROPION-Breast02

5 experts are featured in this series

EP. 3 T-DXd in HER2-Low Disease: DESTINY-Breast06 Data and Patient Selection Insights

5 experts are featured in this series

EP. 4 Emerging Data and Treatment Considerations in HER2 Ultralow Breast Cancer

5 experts are featured in this series

EP. 5 Patient-Reported Outcomes and Quality of Life Data With T-DXd in HER2-(Ultra) Low mBC

5 experts are featured in this series

EP. 6 Proactive AE Management and Prophylactic Strategies With TADCs in Breast Cancer

5 experts are featured in this series

EP. 7 Evolving Paradigms in HER2+ Advanced Breast Cancer With Brain Metastases

5 experts are featured in this series

EP. 8 Precision in CNS Targeting: Optimizing Management of Brain Metastases in HER2+ Breast Cancer

5 experts are featured in this series

EP. 9 Insights From DESTINY-Breast12 Evaluating T-DXd in HER2+ Breast Cancer and Active and Stable Brain Metastases

5 experts are featured in this series

EP. 10 Novel and Emerging Strategies for HER2+ Breast Cancer With Brain Metastases

5 experts are featured in this series

EP. 11 Emerging Frontline, Adjuvant, and Neoadjuvant Strategies with T-DXd in HER2+ Breast Cancer

5 experts are featured in this series

EP. 12 SABCS Highlights and Future Directions in the Treatment of Breast Cancer

Video content above is prompted by the following:

Briefly comment on other novel strategies currently under investigation in HER2+ metastatic breast cancer and discuss their potential impact on future management in this patient population.
• Dr Hurvitz: DESTINY-Breast09 – 1L T-DXd ± pertuzumab in HER2+ mBC

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