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Opinion|Videos|February 12, 2025

Evolving Paradigms in HER2+ Advanced Breast Cancer With Brain Metastases

Author(s)Neil M. Iyengar, MD, Sara A. Hurvitz, MD, FACP , Laura Huppert, MD

Panelists discuss how patients with HER2+ breast cancer frequently develop brain metastases, with recent pivotal trials such as HER2CLIMB and DESTINY-Breast03 demonstrating improved intracranial responses with newer agents such as tucatinib, and how trastuzumab deruxtecan leads to evolving standards of care (SOC) that now incorporate these targeted therapies alongside traditional local therapies.

Episodes in this series

5 experts are featured in this series

EP. 1 Precision Medicine in Breast Cancer: Evolving Paradigms in HER2 Testing and Clinical Implications

5 experts are featured in this series

EP. 2 ADCs in HER2-Low Breast Cancer: Insights From DESTINY-Breast04, TROPiCS-02, and TROPION-Breast02

5 experts are featured in this series

EP. 3 T-DXd in HER2-Low Disease: DESTINY-Breast06 Data and Patient Selection Insights

5 experts are featured in this series

EP. 4 Emerging Data and Treatment Considerations in HER2 Ultralow Breast Cancer

5 experts are featured in this series

EP. 5 Patient-Reported Outcomes and Quality of Life Data With T-DXd in HER2-(Ultra) Low mBC

5 experts are featured in this series

EP. 6 Proactive AE Management and Prophylactic Strategies With TADCs in Breast Cancer

5 experts are featured in this series

EP. 7 Evolving Paradigms in HER2+ Advanced Breast Cancer With Brain Metastases

5 experts are featured in this series

EP. 8 Precision in CNS Targeting: Optimizing Management of Brain Metastases in HER2+ Breast Cancer

5 experts are featured in this series

EP. 9 Insights From DESTINY-Breast12 Evaluating T-DXd in HER2+ Breast Cancer and Active and Stable Brain Metastases

5 experts are featured in this series

EP. 10 Novel and Emerging Strategies for HER2+ Breast Cancer With Brain Metastases

5 experts are featured in this series

EP. 11 Emerging Frontline, Adjuvant, and Neoadjuvant Strategies with T-DXd in HER2+ Breast Cancer

5 experts are featured in this series

EP. 12 SABCS Highlights and Future Directions in the Treatment of Breast Cancer

Video content above is prompted by the following:

Provide a brief overview of the epidemiology and treatment landscape surrounding HER2+ advanced breast cancer with brain metastases. Briefly comment on the current SOC and pivotal trials that have helped shape this treatment space:

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