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Opinion|Videos|March 21, 2025

Expert Insights for Treatment Sequencing in EGFR-Mutant Advanced NSCLC in the Second Line and Beyond

Author(s)Benjamin P. Levy, MD, Misty D. Shields, MD, PhD

Panelists discuss how MARIPOSA-2 (Popat S, et al, ESMO 2024) and the September 2024 FDA approval of amivantamab plus chemo as a second-line option highlight advances in non–small cell lung cancer (NSCLC) treatment. Strategies involve sequencing with emerging therapies like HERTHENA-Lung01, addressing resistance, and central nervous system (CNS) metastases. The complete response letter (CRL) for HER3-DXd and the shift in biologics license application (BLA) status for Dato-DXd from TROPION-Lung05 (Lisberg A, et al, ASCO 2024) will shape clinical practices and resistance management moving forward.

Episodes in this series

2 experts in this video

EP. 1 Expert Insights on Recent Advancements in LS-SCLC

2 experts in this video

EP. 2 Key Updates in the Treatment of ES-SCLC

2 experts in this video

EP. 3 Expert Perspectives on Tarlatamab in ES-SCLC

2 experts in this video

EP. 4 Looking Ahead in SCLC: ADCs and Other Novel Agents

2 experts in this video

EP. 5 Shifting Paradigms With Perioperative Treatment Strategies in Early-Stage NSCLC

2 experts in this video

EP. 6 Personalizing Adjuvant Targeted Therapy in Early-Stage NSCLC

2 experts in this video

EP. 7 New Targeted Approaches in Unresectable Early-Stage NSCL

2 experts in this video

EP. 8 Navigating New Treatment Options in the Frontline Management of Advanced EGFR-Mutant NSCLC

2 experts in this video

EP. 9 Expert Insights for Treatment Sequencing in EGFR-Mutant Advanced NSCLC in the Second Line and Beyond

2 experts in this video

EP. 10 Latest Advances in the Management of Advanced NSCLC with ALK or ROS1 Mutations

2 experts in this video

EP. 11 Recent Updates in the Management Advanced NSCLC with HER2 or NRG1 Alterations

2 experts in this video

EP. 12 Tailoring Immunotherapy Strategies for Advanced NSCLC

Video content above is prompted by the following:

Briefly comment on MARIPOSA-2 (Popat S, et al. ESMO 2024. Abs LBA54)and the recent FDA approval (September 2024) of combination amivantamab plus chemo as a second-line treatment option.
How are you integrating the MARIPOSA-2 regimen into your clinical practice, and how do you sequence it with other available therapies?
If you use MARIPOSA up front, what is your strategy in the second-line setting?
How do emerging data from the HERTHENA-Lung01 study (Johnson M, et al. ESMO 2023. Abs 1319MO) inform your approach to managing treatment resistance management and CNS metastases?
How might the recent CRL for HER3-DXd impact clinical practice over the next year?
What are your perceptions of the latest data from TROPION-Lung05 and the recent shift in BLA status for Dato-DXd?(Lisberg A, et al. ASCO 2024. Abs 8593)

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