Opinion

Video

Tailoring Immunotherapy Strategies for Advanced NSCLC

Panelists discuss how treatment decisions for advanced non–small cell lung cancer (NSCLC) without actionable mutations depend on factors like PD-L1 status, histology (eg, squamous [SQ]), and biomarkers like STK11/KEAP1. Chemotherapy may be added based on individual patient factors, with promising advancements expected in 2025.

Video content above is prompted by the following:

  • How do you select between mono immunotherapy (IO) and dual IO therapy in patients with advanced NSCLC and no actionable mutations?
  • In which patients do you consider the addition of chemotherapy?
  • How does PD-L1 status influence your decision?
  • What is your preferred management strategy for patients with SQ histology? STK11 or KEAP1? What data influence your treatment approach?
  • What advancements in lung cancer from 2024 will have the most significant impact on your clinical practice in 2025?
  • What do you see as the greatest treatment gaps and unmet needs in the management of advanced NSCLC, and what are the most promising opportunities for future advancements?

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