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Opinion|Videos|March 7, 2025

Personalizing Adjuvant Targeted Therapy in Early-Stage NSCLC

Author(s)Benjamin P. Levy, MD, Misty D. Shields, MD, PhD

Panelists discuss how, in clinical practice, ADAURA (osimertinib) and ALINA (alectinib) are integrated based on EGFR/ALK status, stage, and recurrence risk. Adjuvant therapy duration is typically 3 years. Circulating tumor DNA (ctDNA), minimal residual disease (MRD) from ADAURA (ASCO 2024, Abs 8005) may refine treatment decisions by detecting MRD.

Episodes in this series

2 experts in this video

EP. 1 Expert Insights on Recent Advancements in LS-SCLC

2 experts in this video

EP. 2 Key Updates in the Treatment of ES-SCLC

2 experts in this video

EP. 3 Expert Perspectives on Tarlatamab in ES-SCLC

2 experts in this video

EP. 4 Looking Ahead in SCLC: ADCs and Other Novel Agents

2 experts in this video

EP. 5 Shifting Paradigms With Perioperative Treatment Strategies in Early-Stage NSCLC

2 experts in this video

EP. 6 Personalizing Adjuvant Targeted Therapy in Early-Stage NSCLC

2 experts in this video

EP. 7 New Targeted Approaches in Unresectable Early-Stage NSCL

2 experts in this video

EP. 8 Navigating New Treatment Options in the Frontline Management of Advanced EGFR-Mutant NSCLC

2 experts in this video

EP. 9 Expert Insights for Treatment Sequencing in EGFR-Mutant Advanced NSCLC in the Second Line and Beyond

2 experts in this video

EP. 10 Latest Advances in the Management of Advanced NSCLC with ALK or ROS1 Mutations

2 experts in this video

EP. 11 Recent Updates in the Management Advanced NSCLC with HER2 or NRG1 Alterations

2 experts in this video

EP. 12 Tailoring Immunotherapy Strategies for Advanced NSCLC

Video content above is prompted by the following:

How are you incorporating the ADAURA and ALINA regimens into your clinical practice, and what factors influence your patient selection?
What is your anticipated duration of therapy for patients receiving adjuvant osimertinib or alectinib?
What is the role of ctDNA in early-stage NSCLC, and how may it guide adjuvant therapy decisions? (MRD analysis from ADAURA: John T, ASCO 2024. Abs 8005.

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