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Opinion|Videos|March 14, 2025

New Targeted Approaches in Unresectable Early-Stage NSCL

Author(s)Benjamin P. Levy, MD, Misty D. Shields, MD, PhD

Panelists discuss how osimertinib has been approved for patients with unresectable, EGFR-mutated stage III non–small cell lung cancer (NSCLC) following chemoradiation, based on the LAURA trial, which demonstrated a significant improvement in progression-free survival. In clinical practice, osimertinib is administered as consolidation therapy until disease progression or unacceptable toxicity. Ongoing studies like PACIFIC-9 and PACIFIC-8 are exploring the efficacy of combining durvalumab with other agents, potentially influencing future chemo-immunotherapy strategies in advanced NSCLC.

Episodes in this series

2 experts in this video

EP. 1 Expert Insights on Recent Advancements in LS-SCLC

2 experts in this video

EP. 2 Key Updates in the Treatment of ES-SCLC

2 experts in this video

EP. 3 Expert Perspectives on Tarlatamab in ES-SCLC

2 experts in this video

EP. 4 Looking Ahead in SCLC: ADCs and Other Novel Agents

2 experts in this video

EP. 5 Shifting Paradigms With Perioperative Treatment Strategies in Early-Stage NSCLC

2 experts in this video

EP. 6 Personalizing Adjuvant Targeted Therapy in Early-Stage NSCLC

2 experts in this video

EP. 7 New Targeted Approaches in Unresectable Early-Stage NSCL

2 experts in this video

EP. 8 Navigating New Treatment Options in the Frontline Management of Advanced EGFR-Mutant NSCLC

2 experts in this video

EP. 9 Expert Insights for Treatment Sequencing in EGFR-Mutant Advanced NSCLC in the Second Line and Beyond

2 experts in this video

EP. 10 Latest Advances in the Management of Advanced NSCLC with ALK or ROS1 Mutations

2 experts in this video

EP. 11 Recent Updates in the Management Advanced NSCLC with HER2 or NRG1 Alterations

2 experts in this video

EP. 12 Tailoring Immunotherapy Strategies for Advanced NSCLC

Video content above is prompted by the following:

Please discuss the role of osimertinib in patients with unresectable NSCLC.
Briefly comment on the latest data from the LAURA study and recent approval (September 2024) of osimertinib in this space. (Ramalingam SS, et al. ASCO 2024. LBA4; FDA.gov, FDA approves osimertinib for unresectable NSCLC)
How are you incorporating the LAURA regimen into your practice, and what is your recommended duration of therapy for patients?
How do data from trials like PACIFIC-9 and PACIFIC-8 shape your approach to chemo-immunotherapy combinations in advanced NSCLC?

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