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Opinion|Videos|February 18, 2025

Exploring Data of PI3K/AKT/mTOR Inhibitors in HER2– mBC

Panelists discuss the use of alpelisib in light of the inavolisib approval and the impact of capivasertib (CAPItello-291 trial) on the treatment landscape and sequencing options for HR+/HER2– metastatic breast cancer (mBC).

Episodes in this series

EP. 1 Diagnosis and Risk Stratification for Early-Stage HR+/HER2- Breast Cancer

EP. 1 Diagnosis and Risk Stratification for Early-Stage HR+/HER2- Breast Cancer

EP. 2 CDK4/6 Inhibitors for HR+/HER2- Early Breast Cancer

EP. 2 CDK4/6 Inhibitors for HR+/HER2- Early Breast Cancer

EP. 3 Current Practices for Targeted Therapies and Molecular Testing for HR+/HER2- Metastatic Breast Cancer

EP. 3 Current Practices for Targeted Therapies and Molecular Testing for HR+/HER2- Metastatic Breast Cancer

EP. 4 Exploring 1L and 2L CDK4/6 Inhibitors + Endocrine Therapies

EP. 4 Exploring 1L and 2L CDK4/6 Inhibitors + Endocrine Therapies

EP. 5 Clinical Perspectives: Use of CDK4/6i After CDK4/6i

EP. 5 Clinical Perspectives: Use of CDK4/6i After CDK4/6i

EP. 6 The Current Treatment Landscape of Oral SERDs in Metastatic Breast Cancer

EP. 6 The Current Treatment Landscape of Oral SERDs in Metastatic Breast Cancer

EP. 7 Clinical Findings of Elacestrant, an Oral SERD for ER+/HER2– Metastatic Breast Cancer

EP. 7 Clinical Findings of Elacestrant, an Oral SERD for ER+/HER2– Metastatic Breast Cancer

EP. 8 Emerging Data of Additional SERDs in Metastatic Breast Cancer

EP. 8 Emerging Data of Additional SERDs in Metastatic Breast Cancer

EP. 9 CDK4/6 Inhibitors Plus Novel Agents for ER+/HER2–Advanced or mBC

EP. 9 CDK4/6 Inhibitors Plus Novel Agents for ER+/HER2–Advanced or mBC

EP. 10 Toxicities and Treatment Selection of Endocrine-Based Therapies in HR+/HER2– Breast Cancer

EP. 10 Toxicities and Treatment Selection of Endocrine-Based Therapies in HR+/HER2– Breast Cancer

EP. 11 Genotype-Directed Therapies for HR+/HER2– Advanced Breast Cancer

EP. 11 Genotype-Directed Therapies for HR+/HER2– Advanced Breast Cancer

EP. 12 Exploring Data of PI3K/AKT/mTOR Inhibitors in HER2– mBC

EP. 12 Exploring Data of PI3K/AKT/mTOR Inhibitors in HER2– mBC

EP. 13 Clinical Developments of Antibody-Drug Conjugates (ADCs) in HR+/HER2– mBC

EP. 13 Clinical Developments of Antibody-Drug Conjugates (ADCs) in HR+/HER2– mBC

EP. 14 ADCs: Recent Data of Dato-DXd from TROPION-Breast01

EP. 14 ADCs: Recent Data of Dato-DXd from TROPION-Breast01

EP. 15 Impact of ADC Toxicities and Clinical Decision-Making for mBC

EP. 15 Impact of ADC Toxicities and Clinical Decision-Making for mBC

EP. 16 Continued Advances and Treatment Sequencing for HR+/HER2– Breast Cancer

EP. 16 Continued Advances and Treatment Sequencing for HR+/HER2– Breast Cancer

Video content above is prompted by the following:

Dr. Bardia to Dr. Gradishar: Alpelisib – When and how will alpelisib be used, particularly considering the inavolisib approval?

Dr. Bardia to Dr. Gradishar: Capivasertib – How has the approval of capivasertib (CAPItello-291) shifted the treatment landscape and sequencing options for patients with HR+/HER2–- mBC?

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