FDA Approval Insights: BVd for Relapsed/Refractory Multiple Myeloma: With Surbhi Sidana, MD

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OncLive On Air is a podcast from OncLive^®, which provides oncology professionals with the resources and information they need to provide the best patient care. In both digital and print formats, OncLive covers every angle of oncology practice, from new technology to treatment advances to important regulatory decisions.

In today’s episode, the discussion features Surbhi Sidana, MD, an associate professor of medicine (blood and marrow transplantation and cellular therapy) and leader of the Myeloma CAR-T/Immunotherapy Program at Stanford University/Stanford Medicine, as well as a member of the Stanford Cancer Institute, who provided clinical and regulatory perspectives on the FDA approval of belantamab mafodotin-blmf (Blenrep) in combination with bortezomib (Velcade) and dexamethasone (BVd) for adult patients with relapsed or refractory multiple myeloma who have received at least 2 prior lines of therapy, including a proteasome inhibitor and an immunomodulatory agent. The approval was supported by findings from the phase 3 DREAMM-7 trial (NCT04246047).

In this exclusive interview, Dr Sidana reviewed the clinical rationale and study design underlying DREAMM-7, summarized the key efficacy and safety outcomes informing the BVd label, and discussed practical considerations for incorporating a belantamab mafodotin–based regimen into real-world treatment sequencing. She also highlighted treatment implementation nuances, such as monitoring and management strategies for ocular toxicity, and contextualized where this treatment option may fit in the myeloma treatment paradigm alongside other BCMA-directed approaches, with attention to remaining gaps in care and ongoing areas of investigation aimed at optimizing patient selection and outcomes.

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