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Opinion|Videos|June 26, 2024

First-Line Treatment Options in HR+/HER2- Locally Advanced and Metastatic Breast Cancer and Challenges with Treatment Resistance

Author(s)Adam M. Brufsky, MD, PhD, Erika P. Hamilton, MD

Medical experts share their strategies for choosing initial treatment options for HR+/HER2- locally advanced or metastatic breast cancer, debating the most effective frontline therapies based on clinical trial evidence, while also discussing their aspirations for a new standard of care, and the challenges of managing disease progression.

Episodes in this series

This series features 2 KOLs

EP. 1 Biomarker Testing Best Practices in HR+/HER2- Locally Advanced or Metastatic Breast Cancer

This series features 2 KOLs

EP. 2 First-Line Treatment Options in HR+/HER2- Locally Advanced and Metastatic Breast Cancer and Challenges with Treatment Resistance

Video 2 - 2 KOLs are featured in, "Mechanisms of Resistance after 1L CDK4/6i + ET: The PI3K/AKT/PTEN Pathway"

EP. 3 Mechanisms of Resistance after 1L CDK4/6i + ET: The PI3K/AKT/PTEN Pathway

Video 4 - 2 KOLs are featured in, "Clinical Decision Making to Overcome Treatment Resistance in 2L HR+ HER2- mBC"

EP. 4 Clinical Decision Making to Overcome Treatment Resistance in 2L HR+/HER2- Locally Advanced or Metastatic Breast Cancer

Adam M. Brufsky, MD, PhD, and Erika P. Hamilton, MD, experts on breast cancer

EP. 5 Targeted Therapies in HR+/HER2- Locally Advanced or Metastatic Breast Cancer: CAPItello-291

Video 6 - 2 KOLs are featured in, "Other trials of note investigating targeted therapies in later line HR+/HER2- mBC"

EP. 6 Other Trials of Note Investigating Targeted Therapies in Later-line HR+/HER2- Locally Advanced or Metastatic Breast Cancer

Video 7 - 2 KOLs are featured in, "Adverse Event Data and Management for Optimal Quality of Life in HR+/HER2- mBC"

EP. 7 Adverse Event Monitoring and Management in HR+/HER2- Locally Advanced and Metastatic Breast Cancer

Video 8 - 2 KOLs are featured in, "Emerging Trials in the Management of HR+/HER2- mBC"

EP. 8 Emerging Trials in the Management of HR+/HER2- Locally Advanced or Metastatic Breast Cancer

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