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Opinion|Videos|July 2, 2024

Mechanisms of Resistance after 1L CDK4/6i + ET: The PI3K/AKT/PTEN Pathway

Author(s)Adam M. Brufsky, MD, PhD, Erika P. Hamilton, MD

Key opinion leaders explore the mechanisms of resistance that can develop after endocrine therapy and CDK4/6 inhibitor treatment in HR+/HER2- locally advanced or metastatic breast cancer, emphasizing the uncertain etiology of resistance and current hypotheses, while also examining biomarkers that may predict resistance to CDK4/6 inhibitors and endocrine therapy.

Episodes in this series

This series features 2 KOLs

EP. 1 Biomarker Testing Best Practices in HR+/HER2- Locally Advanced or Metastatic Breast Cancer

This series features 2 KOLs

EP. 2 First-Line Treatment Options in HR+/HER2- Locally Advanced and Metastatic Breast Cancer and Challenges with Treatment Resistance

Video 2 - 2 KOLs are featured in, "Mechanisms of Resistance after 1L CDK4/6i + ET: The PI3K/AKT/PTEN Pathway"

EP. 3 Mechanisms of Resistance after 1L CDK4/6i + ET: The PI3K/AKT/PTEN Pathway

Video 4 - 2 KOLs are featured in, "Clinical Decision Making to Overcome Treatment Resistance in 2L HR+ HER2- mBC"

EP. 4 Clinical Decision Making to Overcome Treatment Resistance in 2L HR+/HER2- Locally Advanced or Metastatic Breast Cancer

Adam M. Brufsky, MD, PhD, and Erika P. Hamilton, MD, experts on breast cancer

EP. 5 Targeted Therapies in HR+/HER2- Locally Advanced or Metastatic Breast Cancer: CAPItello-291

Video 6 - 2 KOLs are featured in, "Other trials of note investigating targeted therapies in later line HR+/HER2- mBC"

EP. 6 Other Trials of Note Investigating Targeted Therapies in Later-line HR+/HER2- Locally Advanced or Metastatic Breast Cancer

Video 7 - 2 KOLs are featured in, "Adverse Event Data and Management for Optimal Quality of Life in HR+/HER2- mBC"

EP. 7 Adverse Event Monitoring and Management in HR+/HER2- Locally Advanced and Metastatic Breast Cancer

Video 8 - 2 KOLs are featured in, "Emerging Trials in the Management of HR+/HER2- mBC"

EP. 8 Emerging Trials in the Management of HR+/HER2- Locally Advanced or Metastatic Breast Cancer

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