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Opinion|Videos|March 31, 2025

FLAURA, FLAURA2, and MARIPOSA: Key Takeaways to Impact First-Line Treatment Approach

Author(s)Christine M. Lovly, MD, PhD, Balazs Halmos, MD, MS

Panelists discuss how the FLAURA, FLAURA2, and MARIPOSA trials have reshaped first-line therapy for EGFR-mutant non–small cell lung cancer. FLAURA established osimertinib as superior to first-generation tyrosine kinase inhibitors. FLAURA2 showed added benefit with chemotherapy. MARIPOSA highlighted amivantamab-lazertinib as a strong alternative, refining treatment choices.

Episodes in this series

2 experts in this video

EP. 1 Brief Overview of the Treatment Landscape of First-Line EGFRm NSCLC

2 experts in this video

EP. 2 FLAURA, FLAURA2, and MARIPOSA: Key Takeaways to Impact First-Line Treatment Approach

2 experts in this video

EP. 3 Clinical Factors to Consider When Choosing a Treatment Strategy

2 experts in this video

EP. 4 Treatment Strategies to Manage AEs in EGFRm NSCLC

2 experts in this video

EP. 5 The Multidisciplinary Team’s Role in EGFRm NSCLC Management

2 experts in this video

EP. 6 Role of Rebiopsy at Disease Progression in EGFRm NSCLC

2 experts in this video

EP. 7 Treatment Sequencing in Disease Progression in EGFRm NSCLC

2 experts in this video

EP. 8 Looking Into the Future and at Unmet Needs in EGFRm NSCLC

Video content above is prompted by the following:

Can you walk us through how the FLAURA, FLAURA2, and MARIPOSA data have influenced your approach to first-line therapy? What aspects of these trials were most compelling?
- FLAURA: Ramalingam SS, et al. ESMO 2019. Abstract LBA5_PR. J. Soria, FLAURA_NEJM_2017,
- FLAURA2: D. Planchard, FLAURA2_NEJM_2023
- MARIPOSA: M. Campelo ESMO 2024 Abstract 5M0, E. Felip ASCO 2024 Abstract 8504

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