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Opinion|Videos|March 31, 2025

Brief Overview of the Treatment Landscape of First-Line EGFRm NSCLC

Author(s)Christine M. Lovly, MD, PhD, Balazs Halmos, MD, MS

Panelists discuss how the first-line treatment landscape for EGFR-mutated non–small cell lung cancer (NSCLC) primarily includes EGFR tyrosine kinase inhibitors, with osimertinib as the preferred monotherapy due to its efficacy and central nervous system penetration. Balancing efficacy and safety remain challenging, particularly regarding resistance and adverse effects. Although osimertinib monotherapy is widely used, combination strategies (eg, chemotherapy or antiangiogenic agents) are being explored to enhance outcomes. Treatment decisions are guided by mutation type, patient factors, and emerging clinical data.

Episodes in this series

2 experts in this video

EP. 1 Brief Overview of the Treatment Landscape of First-Line EGFRm NSCLC

2 experts in this video

EP. 2 FLAURA, FLAURA2, and MARIPOSA: Key Takeaways to Impact First-Line Treatment Approach

2 experts in this video

EP. 3 Clinical Factors to Consider When Choosing a Treatment Strategy

2 experts in this video

EP. 4 Treatment Strategies to Manage AEs in EGFRm NSCLC

2 experts in this video

EP. 5 The Multidisciplinary Team’s Role in EGFRm NSCLC Management

2 experts in this video

EP. 6 Role of Rebiopsy at Disease Progression in EGFRm NSCLC

2 experts in this video

EP. 7 Treatment Sequencing in Disease Progression in EGFRm NSCLC

2 experts in this video

EP. 8 Looking Into the Future and at Unmet Needs in EGFRm NSCLC

Video content above is prompted by the following:

Please provide a brief overview of the treatment landscape of first-line treatment for patients with EGFR-mutated NSCLC.
What challenges have you faced in balancing efficacy and safety in EGFR-targeted therapies?
Currently, what guides your first-line treatment decisions for patients with EGFR-mutated NSCLC? Are you using osimertinib monotherapy or combination approaches?

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