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Opinion|Videos|April 14, 2025

Role of Rebiopsy at Disease Progression in EGFRm NSCLC

Author(s)Christine M. Lovly, MD, PhD, Balazs Halmos, MD, MS

Panelists discuss how second-line therapy after osimertinib monotherapy depends on resistance mechanisms. If MET amplification, consider MET inhibitors plus EGFR tyrosine kinase inhibitors (TKIs). For C797S mutation, potential options include first- or third-generation EGFR TKI combinations. Chemotherapy remains a key fallback.

Episodes in this series

2 experts in this video

EP. 1 Brief Overview of the Treatment Landscape of First-Line EGFRm NSCLC

2 experts in this video

EP. 2 FLAURA, FLAURA2, and MARIPOSA: Key Takeaways to Impact First-Line Treatment Approach

2 experts in this video

EP. 3 Clinical Factors to Consider When Choosing a Treatment Strategy

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EP. 4 Treatment Strategies to Manage AEs in EGFRm NSCLC

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EP. 5 The Multidisciplinary Team’s Role in EGFRm NSCLC Management

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EP. 6 Role of Rebiopsy at Disease Progression in EGFRm NSCLC

2 experts in this video

EP. 7 Treatment Sequencing in Disease Progression in EGFRm NSCLC

2 experts in this video

EP. 8 Looking Into the Future and at Unmet Needs in EGFRm NSCLC

Video content above is prompted by the following:

Regarding treatment sequencing, how do you approach second-line therapy after osimertinib monotherapy?

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