Frontline Therapy for Lower-Risk MDS: Global Perspectives and Treatment Selection Strategies

Author(s):

Guillermo Garcia-Manero, MD,Rami Komrokji, MD

The experts describe their strategies for selecting first-line treatments in lower-risk myelodysplastic syndrome patients, focusing on the key factors that inform their sequencing decisions in frontline therapy.

EP: 1.Navigating Myelodysplastic Syndromes: Updates to WHO & ICC Guidelines, IPSS-M, and Risk Stratification

EP: 2.Dr Oliva on Addressing Challenges in Treating Lower-Risk MDS 

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EP: 3.Frontline Therapy for Lower-Risk MDS: Global Perspectives and Treatment Selection Strategies

EP: 4.Review of the COMMANDS Trial

EP: 5.Perceptions of the EHA 2024 Full Analysis of the COMMANDs Trial

EP: 6.Clinical Implications of COMMANDS Trial in Clinical Practice

EP: 7.Treatment Decision-Making Based on the COMMANDS Trials

EP: 8.Exploring Biomarker Analysis, Real-World Data, and Quality of Life in LR-MDS: Insights from EHA 2024

EP: 9.Dr.'s Cluzeau and Komrokji on Utilization Patterns of luspatercept in LR-MDS EHA 2024 Data

EP: 10.Safety Profile of Available Frontline Treatments LR-MDS

EP: 11.1L treatment of lower-risk MDS beyond luspatercept

EP: 12.Sequencing Second-Line Treatments for LR-MDS

EP: 13.Perspectives of IMerge Study

EP: 14.Real-World Evidence and Emerging Therapies in Lower-Risk MDS: Insights from EHA 2024

EP: 15.EHA 2024 Future Directions in Lower-Risk MDS Treatment: Emerging Data, Approvals, and Guideline Updates

EP: 16.Final Thoughts on EHA 2024 Data for Lower-Risk MDS

Dr Garcia-Manero to panelist: Please outline your current approach to 1L treatment selection for patients with lower-risk MDS.
1. What factors guide your frontline selection of therapy?
2. How does your approach compare between U.S. and non-U.S. physicians?