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Opinion|Videos|April 24, 2025

Future of Bispecifics and CAR T in R/R MM

Author(s)Andre H. Goy, MD, Jamie Koprivnikar, MD, Harsh Parmar, MD

Panelists discuss how the preliminary results from the IMMagine-1 trial (ASH 2024, abstract #1031) on anitocabtagene autoleucel highlight the evolving role of bispecifics and chimeric antigen receptor (CAR) T-cell therapies in the treatment landscape for relapsed/refractory multiple myeloma (R/R MM).

Episodes in this series

3 experts in this video

EP. 1 Welcome to This OncLive Peer Exchange: Highlighting Key Abstracts From ASH 2024

3 experts in this video

EP. 2 Insights From the Comparative Efficacy and Safety of Ciltacabtagene Autoleucel and Idecabtagene Vicleucel in Real-World Relapsed/Refractory Multiple Myeloma: A Retrospective Intention-to-Treat Analysis

3 experts in this video

EP. 3 Application of Real-World Evidence in Selecting CAR T in R/R MM

3 experts in this video

EP. 4 Overview of iMMagine-1 Trial: Phase 2 Registrational Study of Anitocabtagene Autoleucel for the Treatment of R/R MM

3 experts in this video

EP. 5 Choosing Between Bispecifics and CAR T: Real-World Implications in R/R MM

3 experts in this video

EP. 6 Future of Bispecifics and CAR T in R/R MM

3 experts in this video

EP. 7 Overview of the 5-Year Follow-Up Analysis From ZUMA-5: A Phase 2 Trial of Axi-Cel in R/R Indolent NHL

3 experts in this video

EP. 8 Key Takeaways From Iopofosine I 131 in Previously Treated Patients With Waldenstrom Macroglobulinemia (WM) in the CLOVER-WaM Trial

3 experts in this video

EP. 9 Overview of the Fixed-Duration Epcoritamab + R-Mini-CHOP in Patients With Previously Untreated DLBCL Ineligible for Full-Dose R-CHOP: Updated Results from Arm 8 of the Epcore NHL-2 Trial

3 experts in this video

EP. 10 Insights From Liso-cel Combined With Ibr for R/RCLL/SLL: Primary Results From the Open-Label, Phase 1/2 Transcend CLL 004 Study

3 experts in this video

EP. 11 Implications of BTK Inhibitors Combined With CAR-T in R/R CLL/SLL

3 experts in this video

EP. 12 Overview of ZUMA-2 Cohorts 1-3: Use of Brexu-cel in R/R MCL

3 experts in this video

EP. 13 Insights From Augmented Hyper-CVAD (AHCVAD), a Pediatric-Inspired Regimen for Adults Younger Than 50 Years With ALL

3 experts in this video

EP. 14 Key Takeaways From ASH 2024

3 experts in this video

EP. 15 Looking Into the Future of AML Treatments

3 experts in this video

EP. 16 Looking Ahead For the Treatments of R/R MM

3 experts in this video

EP. 17 Recommendations For Future Clinical Trials in R/R MM

3 experts in this video

EP. 18 Treatment and Management of MM with Amyloidosis

3 experts in this video

EP. 19 Highlighting the Key Takeaways From ASH 2024

Video content above is prompted by the following:

Future of Bispecifics and CAR T in R/R MM:

The treatment landscape for R/R MM is evolving, with CAR T therapies and bispecific antibodies emerging as key modalities:

CAR T Therapy: Anitocabtagene autoleucel adds to the growing body of evidence supporting personalized, deep, and durable responses in R/R MM, although accessibility and manufacturing time remain challenges.
Bispecific Antibodies: Off-the-shelf alternatives offer flexibility and repeated dosing advantages, with ongoing trials optimizing sequencing and combination strategies.

Future research will focus on sequencing, combination approaches, and bridging strategies to enhance outcomes and accessibility in R/R MM treatment.

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