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Opinion|Videos|February 10, 2025

KN-522: Clinical Implications and Insights Into Clinical Practice

Author(s)Rebecca A. Shatsky, MD, Casey Degen, MD

Panelists highlight the KN-522 study and discuss how updated KEYNOTE-522 data influence their selection of patients for pembrolizumab-containing regimens, focusing on factors that guide the decision to recommend immunotherapy and how to approach patients with borderline indications.

Episodes in this series

EP. 1 NATALEE and monarchE: Clinical Data Review and Insights Into Treating High-Risk HR+/HER2_ Early-Stage Breast Cancer

EP. 1 NATALEE and monarchE: Clinical Data Review and Insights Into Treating High-Risk HR+/HER2_ Early-Stage Breast Cancer

EP. 2 Adjuvant CDK 4/6 Inhibitors for High-Risk HR+/HER2– Early Breast Cancer: Toxicity Management and Real-World Data

EP. 2 Adjuvant CDK 4/6 Inhibitors for High-Risk HR+/HER2– Early Breast Cancer: Toxicity Management and Real-World Data

EP. 3 BRCA Testing in Early-Stage and Metastatic Breast Cancer

EP. 3 BRCA Testing in Early-Stage and Metastatic Breast Cancer

EP. 4 OlympiA: Data Updates From SABCS 2024

EP. 4 OlympiA: Data Updates From SABCS 2024

EP. 5 Role of PARP Inhibitors in Somatic BRCA Mutations and Data Update for PARP Inhibitors

EP. 5 Role of PARP Inhibitors in Somatic BRCA Mutations and Data Update for PARP Inhibitors

EP. 6 KN-522: Clinical Implications and Insights Into Clinical Practice

EP. 6 KN-522: Clinical Implications and Insights Into Clinical Practice

EP. 7 Sequencing Sections for Patients With Both BRCA Mutations and Early-Stage TNBC

EP. 7 Sequencing Sections for Patients With Both BRCA Mutations and Early-Stage TNBC

EP. 8 SABCS 2024: Promising Studies in HR+ and HER2– mBC and Early-Stage TNBC

EP. 8 SABCS 2024: Promising Studies in HR+ and HER2– mBC and Early-Stage TNBC

Video content above is prompted by the following:

Dr. Shatsky please highlight the KN-522 study briefly before moving into discussion>>transition to>>Dr Shatsky asks Dr Degen:Based on updated KEYNOTE-522 data, how do you select patients for pembrolizumab-containing regimens?
1. What factors influence your decision to recommend immunotherapy?
2. How do you approach patients with borderline indications?

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