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Opinion|Videos|January 27, 2025

Adjuvant CDK 4/6 Inhibitors for High-Risk HR+/HER2– Early Breast Cancer: Toxicity Management and Real-World Data

Author(s)Rebecca A. Shatsky, MD, Casey Degen, MD

Panelists discuss the factors influencing the choice between abemaciclib and ribociclib for adjuvant CDK4/6 inhibitor therapy, including patient characteristics and safety profiles, and explore strategies for toxicity management, maintaining dose intensity, and addressing adherence or toxicity challenges in real-world clinical practice.

Episodes in this series

EP. 1 NATALEE and monarchE: Clinical Data Review and Insights Into Treating High-Risk HR+/HER2_ Early-Stage Breast Cancer

EP. 1 NATALEE and monarchE: Clinical Data Review and Insights Into Treating High-Risk HR+/HER2_ Early-Stage Breast Cancer

EP. 2 Adjuvant CDK 4/6 Inhibitors for High-Risk HR+/HER2– Early Breast Cancer: Toxicity Management and Real-World Data

EP. 2 Adjuvant CDK 4/6 Inhibitors for High-Risk HR+/HER2– Early Breast Cancer: Toxicity Management and Real-World Data

EP. 3 BRCA Testing in Early-Stage and Metastatic Breast Cancer

EP. 3 BRCA Testing in Early-Stage and Metastatic Breast Cancer

EP. 4 OlympiA: Data Updates From SABCS 2024

EP. 4 OlympiA: Data Updates From SABCS 2024

EP. 5 Role of PARP Inhibitors in Somatic BRCA Mutations and Data Update for PARP Inhibitors

EP. 5 Role of PARP Inhibitors in Somatic BRCA Mutations and Data Update for PARP Inhibitors

EP. 6 KN-522: Clinical Implications and Insights Into Clinical Practice

EP. 6 KN-522: Clinical Implications and Insights Into Clinical Practice

EP. 7 Sequencing Sections for Patients With Both BRCA Mutations and Early-Stage TNBC

EP. 7 Sequencing Sections for Patients With Both BRCA Mutations and Early-Stage TNBC

EP. 8 SABCS 2024: Promising Studies in HR+ and HER2– mBC and Early-Stage TNBC

EP. 8 SABCS 2024: Promising Studies in HR+ and HER2– mBC and Early-Stage TNBC

Video content above is prompted by the following:

What specific patient characteristics influence your choice between abemaciclib and ribociclib?
In which scenarios would you preferentially choose abemaciclib over ribociclib? Ribociclib over abemaciclib?
Could you discuss your approach to toxicity management with adjuvant CDK4/6 inhibitors?
How do the different safety profiles of abemaciclib and ribociclib impact your patient selection? How do you weigh clinical considerations and comorbidities in your selection considerations?
What strategies have you found most effective for maintaining dose intensity while managing adverse effects?
How has real-world experience with adjuvant CDK4/6 inhibitors matched up with clinical trial data?
What have been your key learnings about patient selection and management?
How do you handle patients who struggle with adherence or toxicity in the first few months?

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