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Opinion|Videos|February 17, 2025

Sequencing Sections for Patients With Both BRCA Mutations and Early-Stage TNBC

Author(s)Rebecca A. Shatsky, MD, Casey Degen, MD

Panelists discuss factors influencing the decision to continue adjuvant immunotherapy for patients achieving pathologic complete response (pCR) with pembrolizumab-containing therapy, weighing the benefits against risks and considering the role of biomarkers. They also explore sequencing decisions for patients with both BRCA mutations and early-stage triple-negative breast cancer (TNBC), focusing on the prioritization of PARP inhibition versus immunotherapy and situations where both may be recommended. Additionally, they discuss approaches to monitoring and managing immune-related adverse events, including baseline screening and ongoing management protocols.

Episodes in this series

EP. 1 NATALEE and monarchE: Clinical Data Review and Insights Into Treating High-Risk HR+/HER2_ Early-Stage Breast Cancer

EP. 1 NATALEE and monarchE: Clinical Data Review and Insights Into Treating High-Risk HR+/HER2_ Early-Stage Breast Cancer

EP. 2 Adjuvant CDK 4/6 Inhibitors for High-Risk HR+/HER2– Early Breast Cancer: Toxicity Management and Real-World Data

EP. 2 Adjuvant CDK 4/6 Inhibitors for High-Risk HR+/HER2– Early Breast Cancer: Toxicity Management and Real-World Data

EP. 3 BRCA Testing in Early-Stage and Metastatic Breast Cancer

EP. 3 BRCA Testing in Early-Stage and Metastatic Breast Cancer

EP. 4 OlympiA: Data Updates From SABCS 2024

EP. 4 OlympiA: Data Updates From SABCS 2024

EP. 5 Role of PARP Inhibitors in Somatic BRCA Mutations and Data Update for PARP Inhibitors

EP. 5 Role of PARP Inhibitors in Somatic BRCA Mutations and Data Update for PARP Inhibitors

EP. 6 KN-522: Clinical Implications and Insights Into Clinical Practice

EP. 6 KN-522: Clinical Implications and Insights Into Clinical Practice

EP. 7 Sequencing Sections for Patients With Both BRCA Mutations and Early-Stage TNBC

EP. 7 Sequencing Sections for Patients With Both BRCA Mutations and Early-Stage TNBC

EP. 8 SABCS 2024: Promising Studies in HR+ and HER2– mBC and Early-Stage TNBC

EP. 8 SABCS 2024: Promising Studies in HR+ and HER2– mBC and Early-Stage TNBC

Video content above is prompted by the following:

Dr. Shatsky asks Dr. Degen: For patients achieving pCR with pembrolizumab-containing therapy, what factors influence your decision about adjuvant immunotherapy continuation? (31: 28 -
- How do you weigh the potential benefits against risks?
- What role do biomarkers play in this decision?
Dr. Degen asks Dr. Shatsky: How do you approach sequencing decisions for patients with both BRCA mutations and early-stage TNBC? (33:51
- What factors guide your prioritization of PARP inhibition versus immunotherapy?
- Are there specific scenarios where you recommend both approaches?
Dr. Shatsky asks Dr. Degen: Could you discuss your approach to immune-related adverse event monitoring and management?
- What is your protocol for baseline screening and ongoing monitoring?

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