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Opinion|Videos|January 27, 2025

NATALEE and monarchE: Clinical Data Review and Insights Into Treating High-Risk HR+/HER2_ Early-Stage Breast Cancer

Author(s)Rebecca A. Shatsky, MD, Casey Degen, MD

Panelists discuss the recent data from the NATALEE and monarchE studies, focusing on adjuvant CDK4/6 inhibitor selection for high-risk HR-positive/HER2-negative (HR+/HER2–) early breast cancer patients, and explore how to interpret the different efficacy signals, particularly the early curve separation observed in monarchE versus NATALEE.

Episodes in this series

EP. 1 NATALEE and monarchE: Clinical Data Review and Insights Into Treating High-Risk HR+/HER2_ Early-Stage Breast Cancer

EP. 1 NATALEE and monarchE: Clinical Data Review and Insights Into Treating High-Risk HR+/HER2_ Early-Stage Breast Cancer

EP. 2 Adjuvant CDK 4/6 Inhibitors for High-Risk HR+/HER2– Early Breast Cancer: Toxicity Management and Real-World Data

EP. 2 Adjuvant CDK 4/6 Inhibitors for High-Risk HR+/HER2– Early Breast Cancer: Toxicity Management and Real-World Data

EP. 3 BRCA Testing in Early-Stage and Metastatic Breast Cancer

EP. 3 BRCA Testing in Early-Stage and Metastatic Breast Cancer

EP. 4 OlympiA: Data Updates From SABCS 2024

EP. 4 OlympiA: Data Updates From SABCS 2024

EP. 5 Role of PARP Inhibitors in Somatic BRCA Mutations and Data Update for PARP Inhibitors

EP. 5 Role of PARP Inhibitors in Somatic BRCA Mutations and Data Update for PARP Inhibitors

EP. 6 KN-522: Clinical Implications and Insights Into Clinical Practice

EP. 6 KN-522: Clinical Implications and Insights Into Clinical Practice

EP. 7 Sequencing Sections for Patients With Both BRCA Mutations and Early-Stage TNBC

EP. 7 Sequencing Sections for Patients With Both BRCA Mutations and Early-Stage TNBC

EP. 8 SABCS 2024: Promising Studies in HR+ and HER2– mBC and Early-Stage TNBC

EP. 8 SABCS 2024: Promising Studies in HR+ and HER2– mBC and Early-Stage TNBC

Video content above is prompted by the following:

Based on the monarchE and NATALEE trials, how do you approach adjuvant CDK4/6 inhibitor selection for patients with high-risk HR+/HER2– early breast cancer?
How do you weigh the different efficacy signals between the trials, particularly the early separation of curves in monarchE versus NATALEE?

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