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Opinion|Videos|February 10, 2025

Role of PARP Inhibitors in Somatic BRCA Mutations and Data Update for PARP Inhibitors

Author(s)Rebecca A. Shatsky, MD, Casey Degen, MD

Panelists discuss how recent data inform their approach to PARP inhibitor use in the metastatic setting, exploring the role of PARP inhibition for somatic BRCA mutations and strategies for managing PALB2 and other homologous recombination deficiency mutations.

Episodes in this series

EP. 1 NATALEE and monarchE: Clinical Data Review and Insights Into Treating High-Risk HR+/HER2_ Early-Stage Breast Cancer

EP. 1 NATALEE and monarchE: Clinical Data Review and Insights Into Treating High-Risk HR+/HER2_ Early-Stage Breast Cancer

EP. 2 Adjuvant CDK 4/6 Inhibitors for High-Risk HR+/HER2– Early Breast Cancer: Toxicity Management and Real-World Data

EP. 2 Adjuvant CDK 4/6 Inhibitors for High-Risk HR+/HER2– Early Breast Cancer: Toxicity Management and Real-World Data

EP. 3 BRCA Testing in Early-Stage and Metastatic Breast Cancer

EP. 3 BRCA Testing in Early-Stage and Metastatic Breast Cancer

EP. 4 OlympiA: Data Updates From SABCS 2024

EP. 4 OlympiA: Data Updates From SABCS 2024

EP. 5 Role of PARP Inhibitors in Somatic BRCA Mutations and Data Update for PARP Inhibitors

EP. 5 Role of PARP Inhibitors in Somatic BRCA Mutations and Data Update for PARP Inhibitors

EP. 6 KN-522: Clinical Implications and Insights Into Clinical Practice

EP. 6 KN-522: Clinical Implications and Insights Into Clinical Practice

EP. 7 Sequencing Sections for Patients With Both BRCA Mutations and Early-Stage TNBC

EP. 7 Sequencing Sections for Patients With Both BRCA Mutations and Early-Stage TNBC

EP. 8 SABCS 2024: Promising Studies in HR+ and HER2– mBC and Early-Stage TNBC

EP. 8 SABCS 2024: Promising Studies in HR+ and HER2– mBC and Early-Stage TNBC

Video content above is prompted by the following:

Dr. Degen asks Dr. Shatsky: In the metastatic setting, how do recent data inform your approach to PARP inhibitor use?
1. What are your thoughts on PARP inhibition for somatic BRCA mutations?
2. How do you approach PALB2 and other homologous recombination deficiency mutations?

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