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Opinion|Videos|January 26, 2024

Navigating BTKi Therapy in R/R CLL: Updates from ELEVATE-RR and ALPINE

Author(s)Catherine C. Coombs, MD, Brian T. Hill, MD, PhD, Ryan W. Jacobs, MD

Panel experts examine considerations for BTKi-based strategies in R/R CLL, highlighting pivotal findings from head-to-head trials, including acalabrutinib vs ibrutinib in ELEVATE-RR and zanubrutinib vs ibrutinib in ALPINE, covering safety, quality of life, and extended follow-up data.

Episodes in this series

A panel of 6 experts on chronic lymphocytic leukemia seated at a long table

EP. 1 Current Front-Line Treatment Options for CLL in 2023

A panel of 6 experts on chronic lymphocytic leukemia

EP. 2 Exploring BTKi Monotherapy in CLL: Long-Term Updates from ELEVATE-TN and SEQUOIA

A panel of 6 experts on chronic lymphocytic leukemia

EP. 3 Strategies for Managing Treatment-Naïve CLL with High-Risk Features

A panel of 6 experts on chronic lymphocytic leukemia

EP. 4 Impact of Off-Target AEs and Treatment Resistance on Evolving 1L Therapy Strategies for CLL

A panel of 6 experts on chronic lymphocytic leukemia

EP. 5 Exploring the Role of BTKi-Based Combination Therapies for Front-line Management of CLL

A panel of 6 experts on chronic lymphocytic leukemia

EP. 6 Treatment Sequencing Strategies for R/R CLL: Impact of Prior 1L Therapy

A panel of 6 experts on chronic lymphocytic leukemia

EP. 7 Navigating BTKi Therapy in R/R CLL: Updates from ELEVATE-RR and ALPINE

A panel of 6 experts on chronic lymphocytic leukemia

EP. 8 Expert Perspectives on Navigating Treatment Selection with BTKis in CLL

A panel of 6 experts on chronic lymphocytic leukemia seated at a long desk

EP. 9 Expert Insights into Navigating Cardiovascular Risks with BTKi Therapy

A panel of 6 experts on chronic lymphocytic leukemia seated at a long desk

EP. 10 Treatment Resistance with Covalent BTKis: Translating Data into Clinical Practice

A panel of 6 experts on chronic lymphocytic leukemia seated at a long desk

EP. 11 Role of Non-Covalent BTKis in R/R CLL: Updates from Ongoing BRUIN and Bellwave Trials

A panel of 6 experts on chronic lymphocytic leukemia seated at a long desk

EP. 12 Emerging Data Surrounding Mechanisms of Resistance to Non-Covalent BTKis

A panel of 6 experts on chronic lymphocytic leukemia seated at a long desk

EP. 13 Expert Insights into Investigation Therapies for CLL

A panel of 6 experts on chronic lymphocytic leukemia seated at a long desk

EP. 14 Future Perspectives on the Treatment Landscape for CLL

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