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Opinion|Videos|February 2, 2024

Treatment Resistance with Covalent BTKis: Translating Data into Clinical Practice

Author(s)Catherine C. Coombs, MD, Brian T. Hill, MD, PhD, Ryan W. Jacobs, MD

Javier Pinilla, MD, PhD explores evidence on molecular mechanisms leading to resistance in second-generation BTK inhibitors for CLL, providing insights from recently presented data at ASH 2023.

Episodes in this series

A panel of 6 experts on chronic lymphocytic leukemia seated at a long table

EP. 1 Current Front-Line Treatment Options for CLL in 2023

A panel of 6 experts on chronic lymphocytic leukemia

EP. 2 Exploring BTKi Monotherapy in CLL: Long-Term Updates from ELEVATE-TN and SEQUOIA

A panel of 6 experts on chronic lymphocytic leukemia

EP. 3 Strategies for Managing Treatment-Naïve CLL with High-Risk Features

A panel of 6 experts on chronic lymphocytic leukemia

EP. 4 Impact of Off-Target AEs and Treatment Resistance on Evolving 1L Therapy Strategies for CLL

A panel of 6 experts on chronic lymphocytic leukemia

EP. 5 Exploring the Role of BTKi-Based Combination Therapies for Front-line Management of CLL

A panel of 6 experts on chronic lymphocytic leukemia

EP. 6 Treatment Sequencing Strategies for R/R CLL: Impact of Prior 1L Therapy

A panel of 6 experts on chronic lymphocytic leukemia

EP. 7 Navigating BTKi Therapy in R/R CLL: Updates from ELEVATE-RR and ALPINE

A panel of 6 experts on chronic lymphocytic leukemia

EP. 8 Expert Perspectives on Navigating Treatment Selection with BTKis in CLL

A panel of 6 experts on chronic lymphocytic leukemia seated at a long desk

EP. 9 Expert Insights into Navigating Cardiovascular Risks with BTKi Therapy

A panel of 6 experts on chronic lymphocytic leukemia seated at a long desk

EP. 10 Treatment Resistance with Covalent BTKis: Translating Data into Clinical Practice

A panel of 6 experts on chronic lymphocytic leukemia seated at a long desk

EP. 11 Role of Non-Covalent BTKis in R/R CLL: Updates from Ongoing BRUIN and Bellwave Trials

A panel of 6 experts on chronic lymphocytic leukemia seated at a long desk

EP. 12 Emerging Data Surrounding Mechanisms of Resistance to Non-Covalent BTKis

A panel of 6 experts on chronic lymphocytic leukemia seated at a long desk

EP. 13 Expert Insights into Investigation Therapies for CLL

A panel of 6 experts on chronic lymphocytic leukemia seated at a long desk

EP. 14 Future Perspectives on the Treatment Landscape for CLL

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