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Opinion|Videos|December 1, 2025

NSCLC Case Study 1: Essential Molecular Testing for New Lung Cancer Diagnosis

Author(s)Martin Dietrich, MD, PhD, Mark A. Socinski, MD

The oncologists delve into the specifics of which non-small cell lung cancer (NSCLC) patients to test. They recommend testing all non-squamous cases and, increasingly, squamous cases as well, especially those with a light smoking history, to ensure no actionable biomarker is missed.

Episodes in this series

2 experts are featured in this series

EP. 1 My Treatment Approach: NSCLC Testing and Management of Complex Cases

2 experts are featured in this series

EP. 2 Tissue is Critical: Best Practices for NSCLC Biomarker Testing

2 experts are featured in this series

EP. 3 NSCLC Case Study 1: Staging & Diagnostic Workup for a Lung Nodule

2 experts are featured in this series

EP. 4 NSCLC Case Study 1: Essential Molecular Testing for New Lung Cancer Diagnosis

2 experts are featured in this series

EP. 5 NSCLC Case Study 1: PD-L1 30% and No Mutations

2 experts are featured in this series

EP. 6 Managing Recurrent NSCLC After Immunotherapy & Surgery

2 experts are featured in this series

EP. 7 The Role of DNA & RNA in Comprehensive Genomic Profiling

2 experts are featured in this series

EP. 8 NSCLC Case Study 2: A Never-Smoker with Neuroendocrine Markers

2 experts are featured in this series

EP. 9 NSCLC Cast Study 2: Deciphering Mixed Histology and Negative Biomarkers in NSCLC

2 experts are featured in this series

EP. 10 NSCLC Case Study 2: Navigating Treatment After a RET Fusion Discovery

2 experts are featured in this series

EP. 11 The Diagnostic Challenge of Rare NSCLC Subtypes and Fusions

2 experts are featured in this series

EP. 12 The Critical Role of Multidisciplinary Teams in NSCLC

2 experts are featured in this series

EP. 13 Lymph Node Status & Tumor Size in Lung Cancer Adjuvant Therapy

2 experts are featured in this series

EP. 14 The Future of Lung Cancer: Screening, Treatment & Unmet Needs

The experts detail the essential biomarker testing for a confirmed adenocarcinoma diagnosis. The immediate priority is testing for EGFR mutations and ALK fusions, as these are highly actionable biomarkers with approved targeted therapy options in both the adjuvant (post-surgery) and metastatic settings.

The experts strongly advocates for using comprehensive genomic profiling (Next-Generation Sequencing or NGS) over single-gene tests. This is especially critical for this patient, who presents with stage III disease. Given the high risk of recurrence and progression to stage IV NSCLC, having a full molecular profile upfront is invaluable. This NGS testing provides a complete dataset that can immediately guide treatment decisions if the disease recurs, ensuring no time is lost in identifying the best personalized therapy options at that critical juncture.

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