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Opinion|Videos|November 24, 2025

My Treatment Approach: NSCLC Testing and Management of Complex Cases

Author(s)Martin Dietrich, MD, PhD, Mark A. Socinski, MD

Two expert oncologists discuss the critical role of comprehensive biomarker testing in non-small cell lung cancer (NSCLC). They emphasize that molecular testing is an essential part of the initial diagnosis, not an optional add-on, as it identifies specific mutations and fusions that dictate the most effective first-line treatment.

Episodes in this series

2 experts are featured in this series

EP. 1 My Treatment Approach: NSCLC Testing and Management of Complex Cases

2 experts are featured in this series

EP. 2 Tissue is Critical: Best Practices for NSCLC Biomarker Testing

2 experts are featured in this series

EP. 3 NSCLC Case Study 1: Staging & Diagnostic Workup for a Lung Nodule

2 experts are featured in this series

EP. 4 NSCLC Case Study 1: Essential Molecular Testing for New Lung Cancer Diagnosis

2 experts are featured in this series

EP. 5 NSCLC Case Study 1: PD-L1 30% and No Mutations

2 experts are featured in this series

EP. 6 Managing Recurrent NSCLC After Immunotherapy & Surgery

2 experts are featured in this series

EP. 7 The Role of DNA & RNA in Comprehensive Genomic Profiling

2 experts are featured in this series

EP. 8 NSCLC Case Study 2: A Never-Smoker with Neuroendocrine Markers

2 experts are featured in this series

EP. 9 NSCLC Cast Study 2: Deciphering Mixed Histology and Negative Biomarkers in NSCLC

2 experts are featured in this series

EP. 10 NSCLC Case Study 2: Navigating Treatment After a RET Fusion Discovery

2 experts are featured in this series

EP. 11 The Diagnostic Challenge of Rare NSCLC Subtypes and Fusions

2 experts are featured in this series

EP. 12 The Critical Role of Multidisciplinary Teams in NSCLC

2 experts are featured in this series

EP. 13 Lymph Node Status & Tumor Size in Lung Cancer Adjuvant Therapy

2 experts are featured in this series

EP. 14 The Future of Lung Cancer: Screening, Treatment & Unmet Needs

Mark Socinski, MD details his institution's approach, which involves two primary testing panels. A rapid 50-gene panel provides results for common, actionable mutations in about seven business days. A more extensive 500-gene panel takes slightly longer but helps identify patients eligible for clinical trials based on rarer genetic alterations. The discussion also notes that other tests, like PD-L1, are often sent to external labs, and plasma-based testing is used. The overarching goal is to use this comprehensive diagnostic information to guide personalized treatment decisions and improve patient management.

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